Meier Erin, Malviya Monica, Kaur Sukhdeep, Ibrahim Jacklynn, Corrigan Andrew, Moawad Andrew, Bukkuri Sathya Alekhya, Trebach Joshua, Su Mark K, Pillai Manju
Department of Pulmonary & Critical Care Medicine, NYU Langone Hospital-Long Island, Mineola, New York, 222 Station Plaza Suite 400, NY 11501, USA.
Department of Internal Medicine, NYU Langone Hospital-Long Island, Mineola, New York, 222 Station Plaza Suite 500, NY 11501, USA.
Case Rep Med. 2023 Jan 13;2023:5058771. doi: 10.1155/2023/5058771. eCollection 2023.
Nitrous oxide is a commonly used inhaled anesthetic for medical procedures, as well as a drug of abuse throughout the world. Excessive nitrous oxide inhalation has been shown to cause a functional vitamin B12 deficiency and hyperhomocysteinemia, which can lead to peripheral neuropathy and hypercoagulability, respectively. While the development of neurologic toxicity from chronic nitrous oxide abuse (i.e., encephalopathy, myelopathy, and neuropathy) has been previously described, the thrombotic potential of chronic nitrous oxide abuse is less known. The authors report two cases of nitrous oxide abuse leading to both neurologic and thrombotic complications.
一氧化二氮是医疗程序中常用的吸入性麻醉剂，也是全球范围内的一种滥用药物。吸入过量一氧化二氮已被证明会导致功能性维生素B12缺乏和高同型半胱氨酸血症，分别可导致周围神经病变和高凝状态。虽然先前已描述过慢性滥用一氧化二氮导致的神经毒性（即脑病、脊髓病和神经病变）的发展情况，但慢性滥用一氧化二氮的血栓形成潜力却鲜为人知。作者报告了两例因滥用一氧化二氮导致神经和血栓形成并发症的病例。
