Sun Wen, Liao Ji-Ping, Hu Yan, Zhang Wei, Ma Jing, Wang Guang-Fa
Guang-Fa Wang Department of Pulmonary and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China.
World J Clin Cases. 2019 Dec 6;7(23):4057-4062. doi: 10.12998/wjcc.v7.i23.4057.
Nitrous oxide (NO) has gained increasing popularity as a recreational drug, causing hallucinations, excitation, and psychological dependence. However, side effects have been reported in recent years. Our case report proposes a correlation among NO, pulmonary embolism (PE), and deep vein thrombosis (DVT) and emphasizes the role of homocysteine (Hcy) in thrombotic events.
A 29-year-old man with long-term NO abuse sought evaluation after acute chest pain. A diagnostic workup revealed PE, DVT, and hyperhomocysteinemia. The patient was successfully treated with thrombolytic and anticoagulant therapy. Moreover, his Hcy level decreased and returned to normal after Hcy-lowering therapy.
Chronic NO abuse might increase the risk of PE and DVT, although there have been few studies previously.
一氧化二氮（NO）作为一种消遣性药物越来越受欢迎，会导致幻觉、兴奋和心理依赖。然而，近年来有副作用的报道。我们的病例报告提出了NO、肺栓塞（PE）和深静脉血栓形成（DVT）之间的相关性，并强调了同型半胱氨酸（Hcy）在血栓形成事件中的作用。
一名长期滥用NO的29岁男性在急性胸痛后寻求评估。诊断检查发现有PE、DVT和高同型半胱氨酸血症。该患者接受溶栓和抗凝治疗后成功治愈。此外，在进行降低Hcy治疗后，他的Hcy水平下降并恢复正常。
尽管之前几乎没有相关研究，但长期滥用NO可能会增加PE和DVT的风险。
