Starling M R, Walsh R A, Lasher J C, Lancaster J L, Blumhardt R
University of Texas Health Science Center, San Antonio.
J Nucl Med. 1987 Nov;28(11):1725-35.
To determine whether variables obtained from Fourier analysis of gated equilibrium radionuclide angiographic (RNA) images can detect and quantify changes in left-ventricular (LV) regional wall motion induced by transient ischemia, 11 chronically instrumented dogs were simultaneously studied with hemodynamic measurements and RNA during control, left circumflex (LCx) coronary artery occlusion, and postocclusion conditions. The dogs were preinstrumented with aortic and LV catheters, electromagnetic aortic and LCx coronary artery flow probes, high-fidelity LV micromanometers, LCx coronary artery occluders, and 4-mm ultrasonic transverse LV diameter and 2-mm regional LV segment crystal pairs. Radionuclide LV regional phase and amplitude variables were calculated for each condition. The absolute changes in LCx region RNA mean, median, and standard deviation of mean phase correlated with the percent changes in LCx segment crystal fractional shortening (r = -0.71, -0.64, and -0.51, respectively; all p less than or equal to 0.01). Similarly, the absolute changes and percent changes in LCx region RNA mean amplitude per pixel correlated with the percent changes in LCx segment crystal fractional shortening (r = 0.89 and 0.94, respectively; both p less than 0.001). When these LCx region RNA phase variables were subgrouped according to mild or severe depression or augmentation in LCx segment crystal fractional shortening, progressive differences were observed between the average values for these subgroups (p less than 0.05 to p less than 0.001). These data, therefore, suggest that these regional RNA phase variables may be able to detect and quantify alterations in LV contraction patterns due to transient ischemia.
为了确定从门控平衡放射性核素血管造影（RNA）图像的傅里叶分析中获得的变量能否检测和量化由短暂性心肌缺血引起的左心室（LV）局部壁运动变化，对11只长期植入仪器的犬在对照、左旋支（LCx）冠状动脉闭塞及闭塞后状态下同时进行血流动力学测量和RNA研究。这些犬预先植入了主动脉和左心室导管、电磁主动脉和LCx冠状动脉血流探头、高保真左心室微测压计、LCx冠状动脉闭塞器，以及4毫米超声横向左心室直径和2毫米局部左心室节段晶体对。计算每种状态下放射性核素左心室局部相位和振幅变量。LCx区域RNA平均、中位数和平均相位标准差的绝对变化与LCx节段晶体缩短分数的百分比变化相关（分别为r = -0.71、-0.64和-0.51；均p≤0.01）。同样，LCx区域RNA每像素平均振幅的绝对变化和百分比变化与LCx节段晶体缩短分数的百分比变化相关（分别为r = 0.89和0.94；均p＜0.001）。当根据LCx节段晶体缩短分数的轻度或重度降低或增加对这些LCx区域RNA相位变量进行亚组划分时，这些亚组平均值之间观察到渐进性差异（p＜0.05至p＜0.001）。因此，这些数据表明这些局部RNA相位变量可能能够检测和量化由短暂性心肌缺血引起的左心室收缩模式改变。
