剪切波弹性成像在颈动脉体瘤评估中的应用：一项初步研究。
Application of the shear wave elastography in the assessment of carotid body tumors: A preliminary study.
作者信息
Zhang Xiaoyan, Zheng Yuehong, Li Jianchu, Zhang Bo
机构信息
Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Vascular Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Front Oncol. 2023 Jan 6;12:1053236. doi: 10.3389/fonc.2022.1053236. eCollection 2022.
OBJECTIVES
To evaluate the elasticity of carotid body tumors (CBTs) by two-dimensional shear wave elastography (SWE).
METHODS
22 pathologically or clinically confirmed CBTs in 16 patients were scanned by SWE. The maximum elasticity value (Emax) and its standard deviation (SDmax) in kPa and m/s for CBTs were obtained by placing a round ROI (2-3 mm) on the stiffest region of the CBTs. Elasticity value was compared between hard and soft groups at manual palpation, benign and malignant groups and among three Shamblin types. The area under the receiver operating characteristic curve (AUC) analysis was performed to evaluate the performance of SWE in the malignancy prediction of CBTs. Sensitivity, specificity and accuracy were calculated. The cut-off value was obtained by using the Youden index.
RESULTS
There were 19 benign CBTs and 3 malignant CBTs. Emax (kPa and m/s) and SDmax (kPa) were significantly higher in the hard group than in the soft group at manual palpation (<0.05); The distribution of Emax in kPa and m/s and SDmax in kPa were different in the three Shamblin types (<0.05), Emax (kPa and m/s)increased from shambling I to Shambling II and Shambling III; Emax (kPa and m/s) were significantly higher in the malignant CBTs than in the benign ones (<0.05). Emax in kPa and m/s had the similar AUC value (AUC=0.947, =1.0000) for the prediction of malignant CBTs. Emax in kPa with the cut-off 124.9kPa showed a sensitivity of 100.0%, specificity of 94.7%, and an accuracy of 95.5% (=8.500, <0.0001); Emax in m/s with the cut-off 5.9m/s showed a sensitivity of 100.0%, specificity of 89.5% and an accuracy of 90.9% for the prediction of malignant CBTs (=9.143, <0.0001).
CONCLUSIONS
Quantitative analysis of SWE obtained the good performance in the elasticity assessment of CBTs.
目的
通过二维剪切波弹性成像（SWE）评估颈动脉体瘤（CBT）的弹性。
方法
对16例患者的22个经病理或临床确诊的CBT进行SWE扫描。通过在CBT最硬区域放置圆形感兴趣区（ROI，2 - 3毫米），获取CBT的最大弹性值（Emax）及其以kPa和m/s为单位的标准差（SDmax）。比较手动触诊时硬组与软组、良性组与恶性组以及三种Shamblin分型之间的弹性值。进行受试者操作特征曲线（AUC）分析以评估SWE在CBT恶性预测中的性能。计算敏感性、特异性和准确性。使用约登指数获得截断值。
结果
有19个良性CBT和3个恶性CBT。手动触诊时，硬组的Emax（kPa和m/s）和SDmax（kPa）显著高于软组（<0.05）；三种Shamblin分型中，以kPa为单位的Emax、以m/s为单位的Emax和以kPa为单位的SDmax分布不同（<0.05），Emax（kPa和m/s）从Shamblin I到Shamblin II和Shamblin III逐渐增加；恶性CBT的Emax（kPa和m/s）显著高于良性CBT（<0.05）。以kPa为单位的Emax和以m/s为单位的Emax在预测恶性CBT时具有相似的AUC值（AUC = 0.947，= 1.0000）。以124.9 kPa为截断值的以kPa为单位的Emax在预测恶性CBT时显示敏感性为100.0%，特异性为94.7%，准确性为95.5%（= 8.500，<0.0001）；以5.9 m/s为截断值的以m/s为单位的Emax在预测恶性CBT时显示敏感性为100.0%，特异性为89.5%，准确性为90.9%（= 9.143，<0.0001）。
结论
SWE的定量分析在CBT弹性评估中表现良好。
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