Chen Qiuchi, Xiong Jie, Ma Yuxi, Wei Jielin, Liu Cuiwei, Zhao Yanxia
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2023 Jan 6;12:1086821. doi: 10.3389/fonc.2022.1086821. eCollection 2022.
Breast cancer (BC) is the most common cancer in females and BC brain metastasis (BCBM) is considered as the second most frequent brain metastasis. Although the advanced treatment has significantly prolonged the survival in BC patients, the prognosis of BCBM is still poor. The management of BCBM remains challenging. Systemic treatments are important to maintain control of central nervous system disease and improve patients' survival. BCBM medical treatment is a rapidly advancing area of research. With the emergence of new targeted drugs, more options are provided for the treatment of BM. This review features currently available BCBM treatment strategies and outlines novel drugs and ongoing clinical trials that may be available in the future. These treatment strategies are discovered to be more efficacious and potent, and present a paradigm shift in the management of BCBMs.
乳腺癌（BC）是女性中最常见的癌症，而乳腺癌脑转移（BCBM）被认为是第二常见的脑转移。尽管先进的治疗方法显著延长了BC患者的生存期，但BCBM的预后仍然很差。BCBM的管理仍然具有挑战性。全身治疗对于维持中枢神经系统疾病的控制和提高患者生存率很重要。BCBM的药物治疗是一个快速发展的研究领域。随着新靶向药物的出现，为脑转移的治疗提供了更多选择。本综述介绍了目前可用的BCBM治疗策略，并概述了未来可能可用的新型药物和正在进行的临床试验。这些治疗策略被发现更有效、更有潜力，并且在BCBM的管理方面呈现出范式转变。
