Mao Fangxin, Su Yonghua, Sun Xiaoying, Li Bin, Liu Peng Fei
Key Laboratory for Ultrafine Materials of Ministry of Education, Shanghai Engineering Research Center of Hierarchical Nanomaterials, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
ACS Omega. 2023 Jan 4;8(2):2733-2739. doi: 10.1021/acsomega.2c07415. eCollection 2023 Jan 17.
Metal-organic frameworks (MOFs) have emerged as prospective antibacterial agents or synergistic agents for their versatile chemical building components and structures. In this work, copper(I) halide MOFs of Cu(I)bpyCl (bpy = 4,4'-bipyridine) composited with AgCl/Ag nanoparticles were synthesized, and their antibacterial activities were measured against and . The attached chlorine in Cu(I)Cl nodes of the MOFs served as loading sites for silver ions, in which AgCl and concomitant metallic Ag nanoparticles were in situ generated. Exceptional antibacterial activity against was realized with a minimum inhibitory concentration (MIC) of ∼7.8 μg mL, while the MIC value was ∼16 μg mL against . Enhanced antibacterial activity against with light irradiation was measured by the disk diffusion method compared with that under dark conditions.
金属有机框架材料（MOFs）因其多样的化学构建组分和结构，已成为有前景的抗菌剂或协同剂。在这项工作中，合成了与AgCl/Ag纳米颗粒复合的Cu(I)bpyCl（bpy = 4,4'-联吡啶）卤化铜（I）MOF，并测定了它们对[具体菌种1]和[具体菌种2]的抗菌活性。MOF的Cu(I)Cl节点中附着的氯作为银离子的负载位点，其中原位生成了AgCl和伴随的金属Ag纳米颗粒。对[具体菌种1]实现了卓越的抗菌活性，最低抑菌浓度（MIC）约为7.8 μg/mL，而对[具体菌种2]的MIC值约为16 μg/mL。通过纸片扩散法测定，与黑暗条件下相比，光照时对[具体菌种1]的抗菌活性增强。
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