Xu Xiaolin, Ding Mengna, Liu Kaiquan, Lv Fujian, Miao Yingchun, Liu Yanmi, Gong Ying, Huo Yuning, Li Hexing
Faculty of Chemical and Environmental Science, Key Laboratory of Environment Chemistry, Qujing Normal University, Qujing, Yunnan, China.
The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry, Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Research Base of Biomimetic Catalysis, and College of Chemistry and Materials Science, Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai, China.
Front Chem. 2023 Feb 15;11:1124303. doi: 10.3389/fchem.2023.1124303. eCollection 2023.
The influence of metal ions, the state of metal salt, and ligands on the sterilization ability of (Metalorganic frameworks) MOFs to effectively achieve sterilization has been investigated in this study. Initially, the MOFs were synthesized by elements of Zn, Ag, and Cd for the same periodic and main group of Cu. This illustrated that the atomic structure of Cu was more beneficial for coordinating with ligands. To further induce the maximum amount of Cu ions in the Cu-MOFs to achieve the highest sterilization, various Cu-MOFs synthesized by the different valences of Cu, various states of copper salts, and organic ligands were performed, respectively. The results demonstrated that Cu-MOFs synthesized by 3, 5-dimethyl-1, 2, 4-triazole and tetrakis (acetonitrile) copper(I) tetrafluoroborate presented the largest inhibition-zone diameter of 40.17 mm towards () under dark conditions. The proposed mechanism of Cu (Ⅱ) in MOFs could significantly cause multiple toxic effects, such as the generation of reactive oxygen species, and lipid peroxidation in cells, when the bacteria was anchored by the Cu-MOFs electrostatic interaction. Finally, the broad antimicrobial properties of Cu-MOFs against (), (), and were demonstrated. In conclusion, the Cu-3, 5-dimethyl-1, 2, 4-triazole MOFs appeared to be potential antibacterial catalysts in the antimicrobial field.
本研究考察了金属离子、金属盐状态和配体对金属有机框架材料（MOFs）有效实现杀菌能力的影响。最初，用与铜处于同一周期和主族的锌、银、镉元素合成MOFs。这表明铜的原子结构更有利于与配体配位。为了进一步诱导铜基金属有机框架材料（Cu-MOFs）中铜离子的最大含量以实现最高杀菌效果，分别制备了由不同价态的铜、不同状态的铜盐和有机配体合成的各种Cu-MOFs。结果表明，由3,5-二甲基-1,2,4-三唑和四氟硼酸四乙腈铜（I）合成的Cu-MOFs在黑暗条件下对（）呈现出最大抑菌圈直径，为40.17毫米。当细菌通过静电相互作用被Cu-MOFs固定时，MOFs中铜（Ⅱ）的作用机制可显著导致多种毒性效应，如活性氧的产生以及细胞内的脂质过氧化。最后，证明了Cu-MOFs对（）、（）和具有广泛的抗菌性能。总之，Cu-3,5-二甲基-1,2,4-三唑MOFs似乎是抗菌领域潜在的抗菌催化剂。
