State Key Laboratory of Medicinal Chemical Biology, Research Center for Analytical Sciences, and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, China.
ACS Appl Bio Mater. 2021 May 17;4(5):3985-3999. doi: 10.1021/acsabm.0c01485. Epub 2021 Jan 11.
Silver-based antibacterial agents have attracted much attention in biomedical fields owing to their high antibacterial activity. Silver ions (Ag) play a significant role in killing bacteria because they can readily adsorb to most biomolecules (DNA, membrane protein, enzymes, or intracellular cofactors) in bacteria to inactivate their functions. In this review, recent advances in the ways of Ag release from silver-contained materials were discussed. As a start, the antibacterial mechanisms of Ag was summarized. Then, the release strategies of Ag from silver-carrying materials have been categorized into two types: (1) passive release and (2) stimuli-responsive release. In particular, the stimuli-responsive materials relying on either endogenous or exogenous stimuli have been rationally designed for eliminating bacteria with high efficacy and selectivity. Future studies should focus on enhancing the controllability of Ag release in the infected sites of the human organs.
银基抗菌剂由于其高抗菌活性，在生物医学领域引起了广泛关注。银离子（Ag）在杀死细菌方面起着重要作用，因为它们可以轻易地吸附到细菌中的大多数生物分子（DNA、膜蛋白、酶或细胞内辅因子）上，从而使其失去功能。在这篇综述中，讨论了银含量材料中银释放的最新进展。首先，总结了 Ag 的抗菌机制。然后，将银载材料中 Ag 的释放策略分为两类：（1）被动释放和（2）刺激响应释放。特别是，基于内源性或外源性刺激的响应性材料已被合理设计用于高效且选择性地消除细菌。未来的研究应侧重于增强 Ag 在人体器官感染部位的释放可控性。
