原发性干燥综合征中 CXCL13 的升高及其与疾病活动的相关性：系统评价和荟萃分析。
Elevated CXCL13 in primary Sjögren's syndrome and its correlation with disease activity: a systematic review and meta-analysis.
机构信息
National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, Sichuan, China.
West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China.
出版信息
Clin Rheumatol. 2022 Sep;41(9):2791-2802. doi: 10.1007/s10067-022-06210-2. Epub 2022 May 26.
OBJECTIVES
CXCL13 levels have been reported to be elevated in primary Sjögren's syndrome (pSS) patients. This study investigated alterations involving the CXCL13/CXCR5 axis in pSS patients and explored the correlation between CXCL13 expression and disease severity.
METHODS
Six databases, including PubMed, Web of Science, Embase, Ovid Medline, China National Knowledge Infrastructure, and Wanfang, were searched. The quality of the included studies was assessed using the Newcastle-Ottawa Scale criteria. We analyzed CXCL13 concentrations in the serum and saliva of pSS patients and healthy controls (HCs). Next, we analyzed the percentage of CXCR5CD4 T cells among CD4 T cells in pSS patients and HCs. Correlations between CXCL13 levels and serological, clinical, and histological parameters of patients were also assessed. Publication bias was determined using funnel plots and Egger's test.
RESULTS
Twenty-three articles were included; of these, 14 studies reported CXCL13 levels, and 5 reported CXCR5CD4 T cell count of pSS patients and HCs. Nine articles covering 32 studies reported correlations between serum CXCL13 levels and serological, clinical, and histological parameters in pSS patients. Expressions of CXCL13 and CXCR5CD4 T cell count were significantly increased in pSS patients compared with those in HCs. There was a positive correlation between CXCL13 levels and serum IgG levels, disease activity indices, and focus score in minor salivary gland biopsy of patients.
CONCLUSIONS
CXCL13 abundance was evidently elevated in pSS patients and correlated with disease activity and can therefore probably be employed as a robust biomarker to monitor and diagnose pSS. Key Points • Serum CXCL13 is significantly elevated in primary Sjögren's syndrome patients. • CXCL13 level correlates with disease severity and activity of primary Sjögren's syndrome. • CXCL13 can probably be used as a robust biomarker to monitor and diagnose primary Sjögren's syndrome.
目的
已有研究报道，趋化因子（C-X-C）配体 13（CXCL13）水平在原发性干燥综合征（pSS）患者中升高。本研究旨在探讨 pSS 患者中 CXCL13/CXCR5 轴的变化，并分析 CXCL13 表达与疾病严重程度的相关性。
方法
检索 PubMed、Web of Science、Embase、Ovid Medline、中国知网和万方数据库，纳入评估 pSS 患者与健康对照者（HC）血清及唾液中 CXCL13 浓度、CXCR5CD4 T 细胞占 CD4 T 细胞百分比的研究，并采用纽卡斯尔-渥太华量表（NOS）评价纳入研究的质量。分析 CXCL13 水平与患者血清学、临床和组织学参数的相关性。采用漏斗图和 Egger 检验评估发表偏倚。
结果
共纳入 23 篇文献，其中 14 篇报道了 CXCL13 水平，5 篇报道了 CXCR5CD4 T 细胞计数。9 篇文章涵盖 32 项研究报道了 pSS 患者血清 CXCL13 水平与血清学、临床和组织学参数之间的相关性。与 HCs 相比，pSS 患者的 CXCL13 表达和 CXCR5CD4 T 细胞计数显著升高。CXCL13 水平与血清 IgG 水平、疾病活动指数和患者小唾液腺活检的焦点评分呈正相关。
结论
pSS 患者血清 CXCL13 明显升高，与疾病活动度相关，因此可能作为监测和诊断 pSS 的有力生物标志物。
关键点
• 原发性干燥综合征患者血清 CXCL13 显著升高。
• CXCL13 水平与疾病严重程度和活动性相关。
• CXCL13 可能作为监测和诊断原发性干燥综合征的有力生物标志物。
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