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挪威风湿病学会关于巨细胞动脉炎患者诊断和治疗的建议。

Norwegian society of rheumatology recommendations on diagnosis and treatment of patients with giant cell arteritis.

作者信息

Haaversen Anne Bull, Brekke Lene Kristin, Bakland Gunnstein, Rødevand Erik, Myklebust Geirmund, Diamantopoulos Andreas P

机构信息

Department of Rheumatology, Martina Hansens Hospital, Bærum, Norway.

Department of Rheumatology, Hospital for Rheumatic Diseases, Haugesund, Norway.

出版信息

Front Med (Lausanne). 2023 Jan 6;9:1082604. doi: 10.3389/fmed.2022.1082604. eCollection 2022.

Abstract

OBJECTIVE

To provide clinical guidance to Norwegian Rheumatologists and other clinicians involved in diagnosing and treating patients with giant cell arteritis (GCA).

METHODS

The available evidence in the field was reviewed, and the GCA working group wrote draft guidelines. These guidelines were discussed and revised according to standard procedures within the Norwegian Society of Rheumatology. The European Alliance of Associations for Rheumatology (EULAR) recommendations for imaging and treatment in large vessel vasculitis and the British Society for Rheumatology (BSR) guidelines for diagnostics and treatment in GCA informed the development of the current guidelines.

RESULTS

A total of 13 recommendations were developed. Ultrasound is recommended as the primary diagnostic test. In patients with suspected GCA, treatment with high doses of Prednisolone (40-60 mg) should be initiated immediately. For patients with refractory disease or relapse, Methotrexate (MTX) should be used as the first-line adjunctive therapy, followed by tocilizumab (TCZ).

CONCLUSION

Norwegian recommendations for diagnostics and treatment to improve management and outcome in patients with GCA were developed.

摘要

目的

为挪威风湿病学家及其他参与巨细胞动脉炎(GCA)患者诊断和治疗的临床医生提供临床指导。

方法

对该领域现有证据进行综述,GCA工作组撰写指南草案。这些指南根据挪威风湿病学会的标准程序进行了讨论和修订。欧洲风湿病协会联盟(EULAR)关于大血管血管炎成像和治疗的建议以及英国风湿病学会(BSR)关于GCA诊断和治疗的指南为当前指南的制定提供了参考。

结果

共制定了13条建议。推荐超声作为主要诊断检查。对于疑似GCA的患者,应立即开始使用高剂量泼尼松龙(40 - 60毫克)进行治疗。对于难治性疾病或复发患者,甲氨蝶呤(MTX)应作为一线辅助治疗药物,其次是托珠单抗(TCZ)。

结论

制定了挪威关于GCA诊断和治疗的建议,以改善GCA患者的管理和预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0350/9853546/fb8ff14b88c1/fmed-09-1082604-g001.jpg

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