Cefai Erika, Galea Marica, Galea Rebecca, Borg Andrew A, Mercieca Cecilia
Department of Rheumatology, Mater Dei Hospital, Msida, Malta.
Mediterr J Rheumatol. 2017 Sep 29;28(3):147-152. doi: 10.31138/mjr.28.3.147. eCollection 2017 Sep.
Giant Cell Arteritis (GCA) remains a challenge both in terms of diagnosis and management as patients may present to several different specialists. The objectives were to determine incidence of biopsy-proven GCA in Malta and to compare the management between rheumatologists and non-rheumatologists.
This was a retrospective observational population study of patients with suspected GCA who underwent a temporal artery biopsy (TAB) between 2012 and 2015. Data collected consisted of demographics, presenting symptoms, TAB histology reports, treatment and outcome. The British Society for Rheumatology (BSR) 2010 guidelines were used as standard of care.
136 patients underwent a TAB for suspected GCA of which 26 were positive. The incidence of biopsy-proven GCA in Malta was 3.82 per 100,000 patient years in the over 50 population. There were 63 patients who were treated as GCA. Only 43.3% of confirmed cases had rheumatology input. TABs requested by rheumatologists were twice more likely to be positive compared to requests by non-rheumatologists (30.5% vs. 14.1%).The majority of patients were started on a Prednisolone dose between 40-60mg. Rheumatologists maintained patients on high doses for at least 1 month in 54% of cases as opposed to 20% under non-rheumatologists. Monitoring was more regular for cases followed up by rheumatologists (40% vs. 21%).
Malta has a low incidence of biopsy proven GCA. Although rheumatologists are more likely to adhere to the recommended guidelines, improvement is needed. Rheumatologists should take the lead to minimise variation and optimise management of GCA.
巨细胞动脉炎(GCA)在诊断和管理方面仍然是一项挑战,因为患者可能会就诊于多个不同专科的医生。本研究的目的是确定马耳他经活检证实的GCA发病率,并比较风湿病专科医生和非风湿病专科医生的管理方式。
这是一项对2012年至2015年间接受颞动脉活检(TAB)的疑似GCA患者的回顾性观察性人群研究。收集的数据包括人口统计学信息、临床表现、TAB组织学报告、治疗情况及结果。采用英国风湿病学会(BSR)2010年指南作为治疗标准。
136例疑似GCA患者接受了TAB,其中26例为阳性。在50岁以上人群中,马耳他经活检证实的GCA发病率为每100,000患者年3.82例。有63例患者按GCA进行治疗。仅43.3%的确诊病例有风湿病专科医生参与。风湿病专科医生要求进行的TAB阳性可能性是非风湿病专科医生的两倍(30.5%对14.1%)。大多数患者开始使用泼尼松龙的剂量为40 - 60mg。54%的病例中,风湿病专科医生让患者维持高剂量至少1个月,而非风湿病专科医生的这一比例为20%。风湿病专科医生随访的病例监测更频繁(40%对21%)。
马耳他经活检证实的GCA发病率较低。尽管风湿病专科医生更有可能遵循推荐指南,但仍需改进。风湿病专科医生应带头尽量减少差异并优化GCA的管理。