Pyogenic spinal infections warrant a total spine MRI.

: retrospective case series. : the presenting clinical symptoms of spinal infections are often nonspecific and a delay in diagnosis can lead to adverse patient outcomes. The morbidity and mortality of patients with multifocal spinal infections is significantly higher compared to unifocal infections. The purpose of the current study was to analyse the risk factors for multifocal spinal infections. : we conducted a retrospective review of all pyogenic non-tuberculous spinal infections treated surgically at a single tertiary care medical center from 2006-2020. The medical records, imaging studies, and laboratory data of 43 patients during this time period were reviewed and analysed after receiving Institutional Review Board approval. Univariate and multivariate analyses were performed to identify factors associated with a multifocal spinal infection. : 15 patients (35 %) had multifocal infections. In univariate analysis, there was a significant association with chronic kidney disease ( ), gender ( ), a white blood cell count ( ), and cervical ( ) or thoracic ( .001) involvement. In multivariate analysis, both cervical and thoracic involvement remained statistically significant ( and , respectively). : patients with infections in the thoracic or cervical region are more likely to have a multifocal infection. Multifocal pyogenic spinal infections remain a common entity and a total spine MRI should be performed to aid in prompt diagnosis.