Gerstmeyer Julius, Gorbacheva Anna, Pierre Clifford, Kraemer Mark, Gold Colin, Hogsett Cameron, Minissale Nick, von Glinski Alexander, Schulte Tobias L, Schildhauer Thomas A, Abdul-Jabbar Amir, Oskouian Rod J, Chapman Jens R
Swedish Neuroscience Institute, Swedish Medical Center, 550 17th Avenue, Suite 500, Seattle, WA 98122, USA.
Department of General and Trauma Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany.
J Clin Med. 2025 Aug 15;14(16):5784. doi: 10.3390/jcm14165784.
Spondylodiscitis is a growing infectious condition with significant morbidity. The impact of multifocal involvement remains understudied. This study compared 90-day all-cause readmission rates between patients with solitary versus multifocal spondylodiscitis and identified the associated risk factors. A retrospective analysis of the 2020 Nationwide Readmissions Database was conducted. Adult patients with primary spondylodiscitis were identified using ICD-10 codes and categorized into solitary or multifocal involvement groups. Demographic, clinical, and surgical data were extracted. Descriptive statistics and multivariate logistic regression were performed. Of 6132 patients, 585 (9.6%) had multifocal disease. Multifocal patients were slightly younger (58.9 vs. 60.3 years; = 0.049); had longer hospital stays (14.7 vs. 11.4 days; < 0.001), time to readmission ( < 0.001); and surgery was more common ( = 0.003). Ninety-day readmission rates were similar (35.6% vs. 34.9%; = 0.766). Type 2 diabetes was the only comorbidity significantly associated with multifocal disease ( = 0.020) and independently predicted readmission (aOR 1.236). Surgery and longer length of stay were protective (aOR 0.743; 0.0990). Multifocal spondylodiscitis is relatively common but not an independent risk factor for readmission. Readmission rates of both cohorts were similar. Surgery and prolonged hospitalization may reduce readmission risk.
脊椎椎间盘炎是一种发病率不断上升的感染性疾病，具有较高的发病率。多灶性受累的影响仍未得到充分研究。本研究比较了单发性与多灶性脊椎椎间盘炎患者90天全因再入院率，并确定了相关危险因素。对2020年全国再入院数据库进行了回顾性分析。使用ICD-10编码识别原发性脊椎椎间盘炎的成年患者，并将其分为单发性或多灶性受累组。提取人口统计学、临床和手术数据。进行描述性统计和多变量逻辑回归分析。在6132例患者中，585例（9.6%）患有多灶性疾病。多灶性疾病患者年龄稍小（58.9岁对60.3岁；P=0.049）；住院时间更长（14.7天对11.4天；P<0.001），再入院时间（P<0.001）；手术更为常见（P=0.003）。90天再入院率相似（35.6%对34.9%；P=0.766）。2型糖尿病是与多灶性疾病显著相关的唯一合并症（P=0.020），并独立预测再入院（调整后比值比1.236）。手术和住院时间延长具有保护作用（调整后比值比0.743；0.0990）。多灶性脊椎椎间盘炎相对常见，但不是再入院的独立危险因素。两组的再入院率相似。手术和延长住院时间可能会降低再入院风险。
