King Shannon Jade, Kondasinghe Jayamangala Sampath
Bethesda Hospital, Claremont, and.
Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Clin Nephrol Case Stud. 2023 Jan 12;11:6-11. doi: 10.5414/CNCS110985. eCollection 2023.
A 72-year-old female was admitted with severe calciphylaxis-associated bilateral leg pain on a background of end-stage renal failure on hemodialysis. Palliative care input was requested, and following transfer to our unit she was commenced on low-dose methadone as adjunctive analgesic therapy. A remarkable and sustained analgesic response was observed. Calciphylaxis is associated with severe pain, and careful consideration of analgesic agents and their pharmacokinetics in patients with end-stage renal failure is required.
一名72岁女性因终末期肾衰竭接受血液透析，伴严重钙化防御相关的双侧腿痛入院。请求姑息治疗介入，转至我们科室后，开始给予低剂量美沙酮作为辅助镇痛治疗。观察到显著且持续的镇痛反应。钙化防御与严重疼痛相关，对于终末期肾衰竭患者，需要仔细考虑镇痛药物及其药代动力学。
