Acree W E, McCargar J W
Department of Chemistry, Kent State University, OH 44242.
J Pharm Sci. 1987 Jul;76(7):575-9. doi: 10.1002/jps.2600760718.
Solubilities are reported for carbazole in binary dibutyl ether plus 1-chlorohexane mixtures at 25 degrees C. Results of these measurements are compared with solution models developed for solubility in systems containing specific solute-solvent interactions. A simple stoichiometric complexation model based on a 1:1 carbazole:dibutyl ether complex could describe the measured solubility to within an average absolute deviation of 1.7%. The calculated equilibrium constant, though, was about one-half of values previously determined from carbazole solubilities in several binary dibutyl ether plus alkane mixtures. A more sophisticated solution model, derived by assuming both 1:1 carbazole: dibutyl ether and carbazole:chlorohexane complexes, could describe the solubilities to within 2.4%. This latter model enables the carbazole-chlorohexane association constant to be calculated from experimental carbazole solubilities and a priori knowledge of the carbazole-dibutyl ether equilibrium constant.
报告了咔唑在25摄氏度下于二丁醚与1-氯己烷二元混合物中的溶解度。将这些测量结果与为含有特定溶质-溶剂相互作用的体系中的溶解度所开发的溶液模型进行了比较。基于1:1咔唑:二丁醚络合物的简单化学计量络合模型能够将测得的溶解度描述在平均绝对偏差1.7%以内。然而，计算得到的平衡常数约为先前从咔唑在几种二丁醚与烷烃二元混合物中的溶解度测定值的一半。通过假设1:1咔唑:二丁醚和咔唑:氯己烷络合物推导得出的更复杂的溶液模型能够将溶解度描述在2.4%以内。后一种模型能够根据咔唑的实验溶解度以及咔唑-二丁醚平衡常数的先验知识来计算咔唑-氯己烷缔合常数。
