Domino E F, Dahlstrom B E, Domino L E, Domino S E
Department of Pharmacology, University of Michigan, Ann Arbor.
J Pharmacol Exp Ther. 1987 Oct;243(1):138-43.
Plasma morphine levels were measured during abrupt withdrawal in four chronically dependent female monkeys. Approximately 12 hr after withdrawal, the morphine plasma concentrations were about 8 to 10 ng/ml, at which time all of the animals showed mild to moderate symptoms of opiate withdrawal. Severity of withdrawal showed a negative correlation (r = -0.93, P less than .001) with the falling phase of plasma morphine. It may be concluded that, under the conditions of this experiment, significant morphine withdrawal symptoms arose despite measurable plasma concentrations of morphine and that the relationship between plasma concentrations and withdrawal may be quantified according to a linear pharmacokinetic model for a given chronic dose (3.0 mg/kg q 6 hr) of morphine.
在四只长期依赖吗啡的雌性猴子突然戒断期间测量了血浆吗啡水平。戒断后约12小时，吗啡血浆浓度约为8至10纳克/毫升，此时所有动物均表现出轻度至中度的阿片类戒断症状。戒断严重程度与血浆吗啡的下降阶段呈负相关（r = -0.93，P <.001）。可以得出结论，在本实验条件下，尽管血浆中吗啡浓度可测，但仍出现了明显的吗啡戒断症状，并且根据给定慢性剂量（3.0毫克/千克，每6小时一次）吗啡的线性药代动力学模型，血浆浓度与戒断之间的关系可以进行量化。
