Furuya Shiro, Fletcher Jason M, Zhao Zijie, Sun Zhongxuan, Lu Qiongshi
University of Wisconsin-Madison, Department of Sociology, USA.
University of Wisconsin-Madison, La Follette School of Public Affairs, USA.
SSM Ment Health. 2022 Dec;2. doi: 10.1016/j.ssmmh.2021.100044. Epub 2021 Dec 8.
The current study evaluates genetic heterogeneities in response to trauma among U.S. young adults. Using Add Health Wave III, which coincidently overlapped with the September 11 attacks, and a depression mean and variance polygenic scores, we investigate how the polygenic scores moderate the causal effect of 9/11 on mental health. Our results show the presence of genetic heterogeneity, where those with high genetic plasticity experience an increase in depressive symptoms following trauma while those with low genetic plasticity do not. While the documented differences in reactions to trauma are important, we also note our ability to predict responses based only on genetic measures are too imprecise to identify susceptible clinical patients. We, therefore, contend that the expected benefits from genetic screening to identify susceptible individuals after trauma are limited. Our results provide novel evidence of a specific source of an additional heterogeneity contributing to the inequality of health following trauma.
当前的研究评估了美国年轻成年人对创伤反应的基因异质性。利用与“9·11”袭击事件巧合重叠的“青少年健康纵向研究”第三波数据以及抑郁均值和方差多基因评分，我们研究了多基因评分如何调节“9·11”事件对心理健康的因果效应。我们的结果显示存在基因异质性，即基因可塑性高的人在创伤后抑郁症状会增加，而基因可塑性低的人则不会。虽然记录在案的创伤反应差异很重要，但我们也注意到，仅基于基因测量来预测反应的能力过于不精确，无法识别易患临床疾病的患者。因此，我们认为创伤后通过基因筛查来识别易感个体的预期益处是有限的。我们的研究结果为导致创伤后健康不平等的另一种异质性的特定来源提供了新证据。
