Dev World Bioeth. 2024 Jun;24(2):66-73. doi: 10.1111/dewb.12390. Epub 2023 Jan 23.
Bio-banking in research elicits numerous ethical issues related to informed consent, privacy and identifiability of samples, return of results, incidental findings, international data exchange, ownership of samples, and benefit sharing etc. In low and middle income (LMICs) countries the challenge of inadequate guidelines and regulations on the proper conduct of research compounds the ethical issues. In addition, failure to pay attention to underlying indigenous worldviews that ought to inform issues, practices and policies in Africa may exacerbate the situation. In this paper we discuss how the African context presents unique and outstanding cultural thought systems regarding the human body and biological materials that can be put into perspective in bio-bank research. We give the example of African ontology of nature presented by John Samwel Mbiti as foundational in adding value to the discourse about enhancing relevance of bio-bank research in the African context. We underline that cultural rites of passage performed on the human body in majority of communities in Africa elicit quintessential perspective on beliefs about handling of human body and human biological tissues. We conclude that acknowledgement and inclusion of African indigenous worldviews regarding the human body is essential in influencing best practices in biobank research in Africa.
生物库研究引发了许多与知情同意、样本的隐私和可识别性、结果的回报、偶然发现、国际数据交换、样本的所有权以及利益分享等相关的伦理问题。在中低收入国家,缺乏关于适当进行研究的指导方针和法规使得这些伦理问题更加复杂。此外,如果不关注应该为非洲的问题、实践和政策提供信息的潜在本土世界观,情况可能会恶化。在本文中,我们讨论了非洲背景下如何提出了独特而杰出的关于人体和生物材料的文化思想体系,可以将其应用于生物库研究中。我们以约翰·萨缪尔·姆比蒂(John Samwel Mbiti)提出的非洲自然本体论为例,为增强生物库研究在非洲背景下的相关性的论述增加了价值。我们强调,在非洲大多数社区中对人体进行的文化过渡仪式,引出了关于处理人体和人体生物组织的观念的基本观点。我们的结论是,承认和纳入非洲本土的人体世界观对于影响非洲生物库研究的最佳实践至关重要。