Okorokov P L, Vasyukova O V, Bezlepkina O B
Endocrinology Research Centre.
Probl Endokrinol (Mosk). 2022 Dec 7;68(6):131-136. doi: 10.14341/probl13208.
The prevalence of obesity and related metabolic disorders in children and adolescents in the Russian Federation is steadily increasing, which requires healthcare professionals to search for new methods of treatment and prevention. The treatment of childhood obesity should be based on a comprehensive approach, including diet therapy, increased physical activity, behavioral therapy and psychological support. To increase the effectiveness of the formation of new eating habits and proper eating behavior, as well as to increase the adherence of children and adolescents to treatment, drug therapy of obesity is used, aimed primarily at reducing appetite. Considering the efficacy and safety of glucagon-like peptide 1 analog (Liraglutide) in adolescents, as well as a small number of gastrointestinal side effects, this drug is promising in the complex treatment of childhood obesity. This review presents an analysis of the literature on non-medicated and drug-based methods of treatment of childhood obesity.
俄罗斯联邦儿童和青少年肥胖症及相关代谢紊乱的患病率正在稳步上升，这就要求医疗保健专业人员寻找新的治疗和预防方法。儿童肥胖症的治疗应基于综合方法，包括饮食疗法、增加体育活动、行为疗法和心理支持。为提高形成新饮食习惯和正确饮食行为的有效性，以及提高儿童和青少年对治疗的依从性，采用了肥胖症药物治疗，主要目的是降低食欲。考虑到胰高血糖素样肽1类似物（利拉鲁肽）在青少年中的疗效和安全性，以及胃肠道副作用较少，这种药物在儿童肥胖症的综合治疗中很有前景。本综述对儿童肥胖症非药物和药物治疗方法的文献进行了分析。
