Service d'endocrinologie, diabète, CHU de Lapeyronie, 371, avenue du Doyen Gaston Giraud, 34090 Montpellier, France.
Service d'endocrinologie, diabétologie, nutrition, Hôpital Nord, Centre Hospitalo-Universitaire-Université Picardie Jules Vernes d'Amiens, 2, Place Victor Pauchet, 80080 Amiens, France.
Ann Endocrinol (Paris). 2023 Apr;84(2):291-297. doi: 10.1016/j.ando.2022.12.424. Epub 2023 Jan 20.
Scientific advances constantly improve our understanding of the mechanisms underlying tumorigenesis, allowing us now to analyze cancer in a more precise manner and to identify at an earlier stage the tumors that have greater risk of aggressive behavior. Understanding neuroendocrine neoplasms at molecular level has enabled increasingly targeted treatments, with safety and efficacy validated in large randomized trials. Moreover, the first studies of targeted therapies after molecular profiling of neuroendocrine neoplasms have shown encouraging results, allowing us to foresee ever more personalized medical treatments in the future. This literature review aims to summarize recent advances in the study of neuroendocrine neoplasms and to show how identification of new mechanisms underlying tumorigenesis can be of benefit in clinical practice.
科学的进步不断加深我们对肿瘤发生机制的理解，使我们现在能够更精确地分析癌症，并在更早的阶段识别出具有更强侵袭性行为风险的肿瘤。在分子水平上对神经内分泌肿瘤的了解使得靶向治疗变得更加安全有效，并且在大型随机试验中得到了验证。此外，对神经内分泌肿瘤进行分子谱分析后进行靶向治疗的首批研究显示出了令人鼓舞的结果，使我们能够预见未来的医疗治疗将更加个性化。这篇文献综述旨在总结神经内分泌肿瘤研究的最新进展，并展示肿瘤发生新机制的鉴定如何在临床实践中受益。
