Shah Saurabh, Joga Ramesh, Kolipaka Tejaswini, Sabnis Dushyantrao Chetan, Khairnar Pooja, Phatale Vivek, Pandey Giriraj, Srivastava Saurabh, Kumar Sandeep
Pharmaceutical Innovation and Translational Research Laboratory (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Department of Regulatory Affairs, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Int J Pharm. 2023 Mar 5;634:122633. doi: 10.1016/j.ijpharm.2023.122633. Epub 2023 Jan 20.
The liquid crystalline phase has attracted tremendous attention from researchers across the globe due to its intriguing properties. In this article, we enumerate the different classes of liquid crystals. Lyotropic liquid crystals (LLCs) exhibit their liquid crystalline nature based on the surrounding solvent media, which opens novel horizons in drug delivery and tissue regeneration. The advantages of LLCs in the said fields and the thermodynamic mechanistic insights responsible for their structural stabilization have been conveyed. Various fabrication and characterization techniques, along with factors influencing the formation of LLCs, have been discussed. Applications in novel therapeutic avenues like bone extracellular matrix, cardiac remodeling, wound management, and implants have been unveiled. Also, regulatory considerations, patent, and clinical portfolios to circumvent the hurdles of clinical translation have been discussed. LLCs could be a promising approach in diverse avenues of tissue regeneration.
由于其引人入胜的特性，液晶相吸引了全球研究人员的极大关注。在本文中，我们列举了不同类型的液晶。溶致液晶（LLCs）基于周围的溶剂介质展现出其液晶性质，这为药物递送和组织再生开辟了新的视野。本文阐述了LLCs在上述领域的优势以及负责其结构稳定的热力学机理见解。讨论了各种制备和表征技术，以及影响LLCs形成的因素。还揭示了其在骨细胞外基质、心脏重塑、伤口处理和植入物等新型治疗途径中的应用。此外，还讨论了监管考量、专利以及克服临床转化障碍的临床项目组合。LLCs可能是组织再生多种途径中的一种有前途的方法。
