Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad 380009, India; Department of Pharmaceutics & Pharm, Technology, K. B. Institute of Pharmaceutical Education and Research, Kadi Sarva Vishwavidyalaya, Gandhinagar 382023, Gujarat, India.
Department of Pharmaceutics, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Shirpur, India.
J Control Release. 2022 Sep;349:533-549. doi: 10.1016/j.jconrel.2022.06.062. Epub 2022 Jul 20.
The necessity for long-term treatments of chronic diseases has encouraged the development of novel long-acting parenteral formulations intending to improve drug pharmacokinetics and therapeutic efficacy. Lately, one of the novel approaches has been developed based on lipid-based liquid crystals. The lyotropic liquid crystal (LLC) systems consist of amphiphilic molecules and are formed in presence of solvents with the most common types being cubic, hexagonal and lamellar mesophases. LC injectables have been recently developed based on polar lipids that spontaneously form liquid crystal nanoparticles in aqueous tissue environments to create the in-situ long-acting sustained-release depot to provide treatment efficacy over extended periods. In this manuscript, we have consolidated and summarized the various type of liquid crystals, recent formulation advancements, analytical evaluation, and therapeutic application of lyotropic liquid crystals in the field of parenteral sustained release drug delivery.
长期治疗慢性病的必要性促使人们开发新型长效注射制剂，旨在改善药物药代动力学和治疗效果。最近，一种新的方法是基于基于脂质的液晶发展而来的。溶致液晶（LLC）体系由两亲性分子组成，并在溶剂存在下形成，最常见的类型是立方、六方和层状中间相。最近开发了基于极性脂质的 LC 注射剂，它们在水组织环境中自发形成液晶纳米颗粒，以形成原位长效持续释放库，从而在延长的时间内提供治疗效果。在本文中，我们总结了各种类型的液晶、最近的制剂进展、溶致液晶的分析评价以及在注射缓控释药物传递领域的治疗应用。
