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COVID-19 患者血细胞中可变剪接的全基因组特征及相关呼吸道感染

Genome-wide characterization of alternative splicing in blood cells of COVID-19 and respiratory infections of relevance.

机构信息

State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, 430072, China.

TaiKang Medical School, Wuhan University, Wuhan, 430071, China.

出版信息

Virol Sin. 2023 Apr;38(2):309-312. doi: 10.1016/j.virs.2023.01.007. Epub 2023 Jan 20.

DOI:10.1016/j.virs.2023.01.007
PMID:36690184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9854207/
Abstract

• The first global exploration of alternative splicing changes in COVID-19 and relevant respiratory diseases. • The specificities and similarities between alternative splicing events in different respiratory diseases. • Identification of regulatory network of RBP and alternative splicing in respiratory diseases. • Defining the interactions of alternative splicing and cell abundance in respiratory diseases.

摘要

• 首次全面探索 COVID-19 及相关呼吸道疾病中的可变剪接变化。 • 不同呼吸道疾病中可变剪接事件的特异性和相似性。 • 鉴定呼吸道疾病中 RBP 和可变剪接的调控网络。 • 定义可变剪接与呼吸道疾病中细胞丰度的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/10176436/4e67a88033be/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/10176436/4e67a88033be/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d09/10176436/4e67a88033be/gr1.jpg

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