Jayadevan Janisha, Manathanath Monisha, Mathew Mekha Mariam, Panicker Unnikrishnan Gopalakrishna
Department of Chemistry, NIT Calicut, Kerala 673601, India.
Department of Chemistry, NIT Calicut, Kerala 673601, India.
Int J Biol Macromol. 2023 Mar 15;231:123286. doi: 10.1016/j.ijbiomac.2023.123286. Epub 2023 Jan 20.
The work highlights the impact of the incorporation of two pharmaceutical plasticizers viz.; glycerol (GLY; hydrophilic) and dibutyl phthalate (DBP; hydrophobic) on the controlled drug release features of a deproteinised natural rubber latex (DNRL) -based matrix. The effects of the plasticizers on the mechanical properties, glass transition temperature (T), water absorption behaviour and porosity of DNRL have been initially investigated. The plasticized membranes have been found to show a hemolysis percentage (HP) of <5 %; confirming its compatibility with human blood. The potential of the modified DNRL membranes to function as drug carriers have been examined with metformin hydrochloride (MET) as a model drug.
这项工作突出了两种药用增塑剂，即甘油（GLY；亲水性）和邻苯二甲酸二丁酯（DBP；疏水性）的加入对基于脱蛋白天然橡胶胶乳（DNRL）的基质的控释药物特性的影响。最初研究了增塑剂对DNRL的机械性能、玻璃化转变温度（T）、吸水行为和孔隙率的影响。已发现增塑膜的溶血率（HP）<5%；证实其与人体血液的相容性。已以盐酸二甲双胍（MET）作为模型药物研究了改性DNRL膜作为药物载体的潜力。
