a Department of Biochemistry and Chemical Technology , Institute of Chemistry, UNESP - Universidade Estadual Paulista , Araraquara , Brazil.
b Bioprocess and Biotechnology Department - FCF , UNESP - Universidade Estadual Paulista , Araraquara , Brazil.
J Biomater Sci Polym Ed. 2017 Dec;28(18):2117-2130. doi: 10.1080/09205063.2017.1377024. Epub 2017 Sep 17.
Natural rubber latex biomedical (NRLb) obtained from the rubber tree Hevea brasiliensis has shown great potential in biomedicine and biomaterial applications. NRLb has been utilized as a physical barrier against infectious agents and in the controlled release of drugs and extracts. In the present work, NRLb was polymerized in a lyophilizer using different volumes of water to control the resultant membrane porosity and characterized regarding the surface morphology, water vapour permeability (WVP), mechanical properties, haemolytic activity and cytotoxicity. The release of bovine serum albumin protein from the latex membranes was evaluated. Drug release rates increased with porosity and membranes were able to control protein release up to 12 h. In addition, WVP increased with the quantity of pores. The cell viability observed for the porous membrane was higher than that noted for conventional membranes. In summary, the porosity control of natural latex membranes can be used to modulate properties and make them suitable for biomedical applications, such as wound dressings, modulated gas-exchange membranes and controlled drug delivery systems.
天然橡胶胶乳生物医学（NRLb）从橡胶树巴西橡胶具有很大的潜力在生物医学和生物材料的应用。NRLb 已被用作对抗传染性病原体的物理屏障，并在药物和提取物的控制释放中得到应用。在本工作中，NRLb 在冷冻干燥器中聚合，使用不同体积的水来控制所得膜的孔隙率，并对其表面形貌、水蒸气透过率（WVP）、机械性能、溶血活性和细胞毒性进行了表征。从胶乳膜中释放牛血清白蛋白蛋白。药物释放速率随孔隙率的增加而增加，且膜能够控制蛋白质释放长达 12 小时。此外，WVP 随孔数量的增加而增加。多孔膜的细胞活力高于常规膜的细胞活力。总之，天然胶乳膜的孔隙率控制可用于调节性质，使其适用于生物医学应用，如伤口敷料、调制气体交换膜和控制药物释放系统。
