Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Hypertens Res. 2023 May;46(5):1122-1131. doi: 10.1038/s41440-023-01175-4. Epub 2023 Jan 24.
The aim of this study was to clarify the relationship between fasting and nonfasting serum triglyceride (TG) levels and the incidence of hypertension in a general Japanese population. We conducted a population-based retrospective cohort study using annual health check-up data of residents of Iki City, Nagasaki Prefecture, Japan. A total of 3202 participants without hypertension at baseline were included in the present analysis. TG levels were classified as quartile 1 (<0.82 mmol/L), quartile 2 (0.83-1.13 mmol/L), quartile 3 (1.14-1.70 mmol/L) and quartile 4 (≥1.71 mmol/L) for men, and as quartile 1 (<0.70 mmol/L), quartile 2 (0.71-0.96 mmol/L), quartile 3 (0.97-1.34 mmol/L) and quartile 4 (≥1.35 mmol/L) for women. The outcome was incident hypertension. During an average follow-up of 4.4 years, 983 participants developed hypertension, according to the Cox proportional hazards model. The annual incidence of hypertension increased with an elevation in TG levels for men (5.88% in quartile 1, 8.30% in quartile 2, 7.62% in quartile 3, and 9.82% in quartile 4). This association was significant, even after adjustment for other risk factors: hazard ratio 1.41 [95% CI 1.07-1.85] for quartile 2, 1.30 [0.99-1.71] for quartile 3, and 1.59 [1.22-2.08] for quartile 4 compared with quartile 1 (p = 0.041 for trend). In contrast, there was no clear association between serum TG levels and the incidence of hypertension after adjustment for confounding factors among women (p = 0.240 for trend). High levels of serum TG were associated with the future incidence of hypertension in a general population of Japanese men but were not associated with that in women. Casual serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study.
本研究旨在阐明空腹和非空腹血清三酰甘油（TG）水平与日本一般人群高血压发病之间的关系。我们对日本长崎县壱岐市居民的年度健康检查数据进行了一项基于人群的回顾性队列研究。本分析共纳入了 3202 名基线时无高血压的参与者。男性 TG 水平分为四分位 1（<0.82mmol/L）、四分位 2（0.83-1.13mmol/L）、四分位 3（1.14-1.70mmol/L）和四分位 4（≥1.71mmol/L），女性 TG 水平分为四分位 1（<0.70mmol/L）、四分位 2（0.71-0.96mmol/L）、四分位 3（0.97-1.34mmol/L）和四分位 4（≥1.35mmol/L）。结局为高血压发病。在平均 4.4 年的随访期间，根据 Cox 比例风险模型，983 名参与者发生了高血压。男性 TG 水平升高，高血压的年发病率也随之升高（四分位 1 为 5.88%，四分位 2 为 8.30%，四分位 3 为 7.62%，四分位 4 为 9.82%）。即使在调整其他危险因素后，这种关联仍然显著：与四分位 1 相比，四分位 2 的风险比为 1.41（95%CI 1.07-1.85），四分位 3 的风险比为 1.30（0.99-1.71），四分位 4 的风险比为 1.59（1.22-2.08）（趋势检验 p=0.041）。相比之下，在调整了女性混杂因素后，血清 TG 水平与高血压发病之间没有明显的关联（趋势检验 p=0.240）。在日本男性普通人群中，高水平的血清 TG 与未来高血压的发病相关，但与女性无关。日本普通人群血清甘油三酯水平与高血压发病的关系：ISSA-CKD 研究。
