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一名患有硬皮病和强直性脊柱炎罕见组合的患者出现的转诊吞咽困难。

Transfer dysphagia in a patient with the rare combination of scleroderma and ankylosing spondylitis.

作者信息

Witt P, Thomas E

出版信息

J Natl Med Assoc. 1987 Sep;79(9):993-4, 996.

PMID:3669094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2625594/
Abstract

Esophageal involvement in scleroderma is generally confined to the body, manifested manometrically as impaired motility and decreased lower esophageal sphincter tone. Pharyngeal dysfunction has not been recognized. This is a report of a patient with the rare combination of scleroderma and ankylosing spondylitis, whose presenting complaint was transfer dysphagia due to impaired relaxation of the upper esophageal spincter as a result of tight overlying cervical skin, or sclerodermatous involvement of the sphincter itself.

摘要

硬皮病累及食管通常局限于食管体部，测压表现为动力障碍和食管下括约肌张力降低。咽部功能障碍尚未得到认识。本文报告1例罕见的硬皮病合并强直性脊柱炎患者，其主要症状是由于颈部上方皮肤紧绷导致食管上括约肌松弛受损，或括约肌本身硬皮病性受累而出现的转送性吞咽困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/2625594/33bb4f0249b8/jnma00924-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/2625594/624fe638fba6/jnma00924-0120-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/2625594/d590a73a873e/jnma00924-0120-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/2625594/8ac997c13b82/jnma00924-0120-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/2625594/33bb4f0249b8/jnma00924-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/2625594/624fe638fba6/jnma00924-0120-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/2625594/d590a73a873e/jnma00924-0120-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/2625594/8ac997c13b82/jnma00924-0120-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6005/2625594/33bb4f0249b8/jnma00924-0122-a.jpg

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本文引用的文献

1
Ankylosing spondylitis, lymphoma and scleroderma--a unique conjunction.强直性脊柱炎、淋巴瘤和硬皮病——一种独特的关联。
Ir J Med Sci. 1982 Nov;151(11):351-2. doi: 10.1007/BF02940222.
2
Letter: HL-A antigens in progressive systemic sclerosis (scleroderma).信函：进行性系统性硬化症（硬皮病）中的人类白细胞抗原
Arthritis Rheum. 1975 Jul-Aug;18(4):381-2. doi: 10.1002/art.1780180418.
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Disorders of the lower esophageal sphincter.
Annu Rev Med. 1975;26:373-90. doi: 10.1146/annurev.me.26.020175.002105.
系统性硬化症与强直性脊柱炎的罕见关联。
Clin Rheumatol. 2005 Nov;24(6):652-4. doi: 10.1007/s10067-004-0980-x. Epub 2004 Aug 27.
4
The microvascular pathogenesis of scleroderma: an hypothesis.硬皮病的微血管发病机制：一种假说。
Ann Intern Med. 1979 Nov;91(5):788-9. doi: 10.7326/0003-4819-91-5-788.
5
Gastroesophageal reflux in esophageal scleroderma: diagnosis and implications.食管硬皮病中的胃食管反流：诊断及意义
Ann Thorac Surg. 1976 Aug;22(2):120-30. doi: 10.1016/s0003-4975(10)63972-0.