Reproductive Medicine Unit, Gruppo Donnamed, Rome, Italy.
Center for Human Reproduction, New York, NY, USA.
Hum Reprod. 2023 Mar 1;38(3):329-333. doi: 10.1093/humrep/dead002.
Double ovarian stimulation (DuoStim), initially only suggested for fertility preservation in cancer patients, is now increasingly also used in routine clinical IVF, especially in poor responders. The claimed rational for this is the alleged existence of multiple follicular waves in a single intermenstrual interval, allowing for retrieval of more oocytes in a single IVF cycle. This commentary argues that this expansion of purpose lacks rationale, evidence, and follow-up. Consequently, we suggest that, unless valid clinical indications have been established, DuoStim be only subject of controlled clinical trials with appropriate experimental consents.
双卵巢刺激（DuoStim）最初仅被建议用于癌症患者的生育力保存，现在在常规临床 IVF 中也越来越多地使用，特别是在反应不良者中。这种做法的理由据称是在单个月经周期中存在多个卵泡波，从而可以在单个 IVF 周期中取出更多的卵子。本文评论认为，这种目的扩张缺乏合理性、证据和后续研究。因此，除非已经确定了有效的临床适应证，否则 DuoStim 只能作为有适当实验同意书的对照临床试验的对象。
