Edward Via College of Osteopathic Medicine, Blacksburg, Virginia, USA.
CEU-San-Pablo University School of Medicine, Madrid, Spain.
Anat Histol Embryol. 2023 May;52(3):490-499. doi: 10.1111/ahe.12905. Epub 2023 Jan 24.
Peripheral nerve injury and the nerves' subsequent repair and regeneration continues to be marked clinically by poor functional recovery. The analysis of nerve morphology is an aspect which may provide an impact on successful clinical outcomes through better prediction of donor and recipient matching. In this study, we evaluated the morphological aspects of the human obturator nerve for a better understanding of its potential in nerve transplantation. Morphological characteristics of donor obturator nerves were analysed, including nerve diameter and length, fascicle count and the ratio of neural to non-neural tissue present within the cross-sectional area of the nerve's epineurium, with respect to laterality and sex. Statistical significance (p < 0.10) was determined for male obturator nerves having an average diameter of 2.67 mm compared to female obturator nerves at 1.91 mm, as well as left obturator nerves having an average of 11.21 fascicles compared to the right having an average of 10.17 fascicles. Strong positive correlations were determined between cross-sectional nerve area and limb size index, as well as between percentage of non-neural tissue and area of non-neural tissue, among males. Separately, strong correlation between percentage of non-neural tissue and area of non-neural tissue among right obturator nerves in males and females was determined . These findings indicate that there are associations and predictions that can be made about nerve morphology and that these when combined with other patient characteristics may enhance patient functional recovery following a peripheral nerve's repair.
周围神经损伤及其后续的修复和再生在临床上一直以功能恢复不良为特征。神经形态学的分析是一个方面,通过更好地预测供体和受体的匹配,可能对成功的临床结果产生影响。在这项研究中,我们评估了人类闭孔神经的形态学方面,以更好地了解其在神经移植中的潜力。分析了供体闭孔神经的形态特征,包括神经直径和长度、束数以及神经外膜横截面积内神经组织与非神经组织的比例,同时考虑了侧别和性别。统计学意义(p<0.10)确定为男性闭孔神经的平均直径为 2.67mm,而女性闭孔神经为 1.91mm,左侧闭孔神经的平均束数为 11.21 束,而右侧闭孔神经的平均束数为 10.17 束。在男性中,还确定了横截面积神经与肢体大小指数之间以及非神经组织比例与非神经组织面积之间存在强烈的正相关关系。此外,还确定了男性和女性右侧闭孔神经中非神经组织比例与非神经组织面积之间存在强烈的相关性。这些发现表明,神经形态学存在关联和预测,这些关联和预测与其他患者特征相结合,可能会增强周围神经修复后患者的功能恢复。