Department of Paediatrics, Brighton and Sussex Medical School, Brighton, UK.
Department of Child Development and Neurodisability, Children's Health Ireland at Tallaght, Dublin, Ireland.
J Hum Nutr Diet. 2023 Aug;36(4):1390-1405. doi: 10.1111/jhn.13143. Epub 2023 Feb 7.
Interest and use of blended diets (BD) for young people who are tube fed has significantly increased in the last decade, driven primarily by the desires of motivated caregivers. This review identified, appraised and synthesised the available evidence on the benefits and complications of BD versus commercial feeds.
A systematic review following PRISMA guidance and registered with PROSPERO was conducted across PubMed, Embase, CINAHL, Scopus and Cochrane up to August 2022.
English language studies including (1) children, (2) original research (interventional and observational) and (3) examination of BD outcomes. Exclusion criteria were (1) unoriginal research or case reports, (2) focus on feeding management, preparations or attitudes and (3) comparing commercial blends only. Data were synthesised using an established narrative synthesis approach using the Mixed Methods Appraisal Tool.
Eight hundred and six database results were identified and 61 were sought for retrieval. A full-text article review revealed seven eligible studies, involving 267 participants (age range 9 months to 26 years). Studies reported differences in gastrointestinal symptoms (n = 222), medication use (n = 119), growth (n = 189) and complications or adverse events (n = 91). The results indicate positive outcomes, particularly in gastrointestinal symptom control, with few reports of mild adverse events in the included studies.
There is a paucity of data in this area and much heterogeneity in the included studies, but the available literature points towards positive outcomes. This is an important and highly relevant topic, and more primary research, ideally using standardised reporting, is required to answer the key questions.
在过去十年中，接受管饲的年轻人对混合饮食（BD）的兴趣和使用显著增加，这主要是出于有意愿的护理人员的需求。本综述旨在确定、评估和综合现有关于 BD 与商业饲料相比的益处和并发症的证据。
按照 PRISMA 指南进行了系统综述，并在 PROSPERO 上进行了注册，检索范围涵盖了 PubMed、Embase、CINAHL、Scopus 和 Cochrane，检索时间截至 2022 年 8 月。
包括（1）儿童，（2）原始研究（干预和观察性研究）和（3）BD 结果评估的英语语言研究。排除标准为（1）非原始研究或病例报告，（2）关注喂养管理、准备或态度，（3）仅比较商业混合物。使用混合方法评估工具采用既定的叙述性综合方法对数据进行综合。
从 806 个数据库结果中确定了 61 项进行检索。对全文文章进行审查后，发现了 7 项符合条件的研究，涉及 267 名参与者（年龄范围为 9 个月至 26 岁）。研究报告了胃肠道症状（n=222）、药物使用（n=119）、生长（n=189）和并发症或不良事件（n=91）的差异。结果表明存在积极的结果，特别是在胃肠道症状控制方面，纳入研究中很少有轻度不良事件的报告。
该领域的数据匮乏，纳入研究的异质性很大，但现有文献表明存在积极的结果。这是一个重要且高度相关的话题，需要更多的原始研究，最好使用标准化报告来回答关键问题。
