Emerg Infect Dis. 2023 Feb;29(2):314-22. doi: 10.3201/eid2902.220950.
Reports of Salmonella enterica I serotype 4,[5],12:i:- infections resistant to ampicillin, streptomycin, sulphamethoxazole, and tetracycline (ASSuT) have been increasing. We analyzed data from 5 national surveillance systems to describe the epidemiology, resistance traits, and genetics of infections with this Salmonella strain in the United States. We found ASSuT-resistant Salmonella 4,[5],12:i:- increased from 1.1% of Salmonella infections during 2009-2013 to 2.6% during 2014-2018; the proportion of Salmonella 4,[5],12:i:- isolates without this resistance pattern declined from 3.1% to 2.4% during the same timeframe. Among isolates sequenced during 2015-2018, a total of 69% were in the same phylogenetic clade. Within that clade, 77% of isolates had genetic determinants of ASSuT resistance, and 16% had genetic determinants of decreased susceptibility to ciprofloxacin, ceftriaxone, or azithromycin. Among outbreaks related to the multidrug-resistant clade, 63% were associated with pork consumption or contact with swine. Preventing Salmonella 4,[5],12:i:- carriage in swine would likely avert human infections with this strain.
报告显示，对氨苄西林、链霉素、磺胺甲恶唑和四环素（ASSuT）具有耐药性的肠炎沙门氏菌血清型 4,[5],12:i:-感染病例不断增加。我们分析了 5 个国家监测系统的数据，以描述这种沙门氏菌在美国的流行病学、耐药特征和遗传学。我们发现，2009-2013 年 ASSuT 耐药性沙门氏菌 4,[5],12:i:-感染占沙门氏菌感染的 1.1%，而在 2014-2018 年则上升至 2.6%；在同一时期，无这种耐药模式的沙门氏菌 4,[5],12:i:-分离株的比例从 3.1%下降至 2.4%。在 2015-2018 年期间测序的分离株中，共有 69%属于同一系统发育群。在该群中，77%的分离株具有 ASSuT 耐药的遗传决定因素，16%的分离株对环丙沙星、头孢曲松或阿奇霉素的敏感性降低。在与多药耐药群相关的暴发中，63%与猪肉消费或接触猪有关。预防猪携带沙门氏菌 4,[5],12:i:-可能会避免人类感染这种菌株。
