Emerg Infect Dis. 2023 Feb;29(2):381-388. doi: 10.3201/eid2902.221422.
Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reducing the global effects of the COVID-19 pandemic.
多项研究表明,中和抗体水平与 COVID-19 的免疫保护相关,并对中和抗体与保护作用之间的关系进行了估算。然而,这些研究的结果在所需中和抗体水平的估计方面存在差异。通过对抗体滴度进行归一化处理,我们发现研究结果在抗体水平与 COVID-19 保护作用之间的关系上趋于一致。这一发现对于规划未来疫苗使用、确定人群免疫力以及减轻 COVID-19 大流行的全球影响具有重要意义。