肠道微生物群与心血管系统之间的免疫交流。
Immune communication between the intestinal microbiota and the cardiovascular system.
作者信息
Ren Hao, Zhu Botao, An Yuze, Xie Feng, Wang Yichuan, Tan Yurong
机构信息
Department of Medical Microbiology, Central South University Changsha, Hunan Provinces, China.
Department of Medical Microbiology, Central South University Changsha, Hunan Provinces, China.
出版信息
Immunol Lett. 2023 Feb;254:13-20. doi: 10.1016/j.imlet.2023.01.007. Epub 2023 Jan 21.
The intestine hosts a large number of microbial communities. Recent studies have shown that gut microbiota-mediated immune responses play a vital role in developing cardiovascular diseases (CVD). Immune cells are extensively infiltrated in the gut and heart tissues, such as T cells, B cells, and macrophages. They play a crucial role in the crosstalk between the heart and gut microbiota. And the microbiota influences the bidirectional function of immune cells in CVD such as myocardial infarction and atherosclerosis, including through metabolites. The mapping of immune cell-mediated immune networks in the heart and gut provides us with new targets for treating CVD. This review discusses the role of immune cells in gut microbiota and cardiac communication during health and CVD.
肠道中存在大量微生物群落。最近的研究表明，肠道微生物群介导的免疫反应在心血管疾病（CVD）的发生发展中起着至关重要的作用。免疫细胞广泛浸润于肠道和心脏组织中，如T细胞、B细胞和巨噬细胞。它们在心脏与肠道微生物群的相互作用中起着关键作用。并且微生物群通过代谢产物等影响免疫细胞在诸如心肌梗死和动脉粥样硬化等心血管疾病中的双向功能。心脏和肠道中免疫细胞介导的免疫网络图谱为我们提供了治疗心血管疾病的新靶点。本综述讨论了免疫细胞在健康和心血管疾病期间肠道微生物群与心脏通讯中的作用。
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