Xi'An Key Laboratory of Pathogenic Microorganism and Tumor Immunity, Xi'An Medical University, Xi'An 710021, China.
Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, People's Republic of China.
Reprod Sci. 2023 Jun;30(6):1746-1757. doi: 10.1007/s43032-023-01169-0. Epub 2023 Jan 24.
Embryo implantation and decidualization are key steps in establishing a successful pregnancy. Defects in embryo implantation and decidualization can cause a series of adverse chain reactions which can contribute to harmful pregnancy outcomes, such as embryo growth retardation, preeclampsia, miscarriage, premature birth, and so on. Approximately 75% of failed pregnancies are considered to be due to embryo implantation failure or defects. Decidualization, characterized by proliferation and differentiation of uterine stromal cells, is one of the essential conditions for blastocyst implantation, placental formation, and maintenance of pregnancy and is indispensable for the establishment of pregnancy in many species. Embryo implantation and decidualization are closely regulated by estrogen and progesterone secreted by the ovaries. Many cellular events and molecular signaling network pathways are involved in this process. This article reviews the recent advances in the molecular mechanisms of estrogen- and progesterone-regulating uterine receptivity establishment, blastocyst implantation, and decidualization, in order to better understand the underlying molecular mechanisms of hormonal regulation of embryo implantation and to develop new strategies for preventing or treating embryo implantation defects and improving the pregnancy rate of women.
胚胎着床和蜕膜化是成功妊娠的关键步骤。胚胎着床和蜕膜化缺陷可导致一系列不良的连锁反应，导致有害的妊娠结局，如胚胎生长迟缓、子痫前期、流产、早产等。大约 75%的妊娠失败被认为是由于胚胎着床失败或缺陷。蜕膜化的特征是子宫基质细胞的增殖和分化，是囊胚着床、胎盘形成和维持妊娠所必需的，对许多物种的妊娠建立是不可或缺的。胚胎着床和蜕膜化受卵巢分泌的雌激素和孕激素的密切调节。这一过程涉及许多细胞事件和分子信号网络途径。本文综述了雌激素和孕激素调节子宫容受性建立、囊胚着床和蜕膜化的分子机制的最新进展，以期更好地理解激素调节胚胎着床的潜在分子机制，并为预防或治疗胚胎着床缺陷和提高妇女妊娠率开发新的策略。
