Department of Pathology, Dr. D.Y Patil Medical College, Hospital and Research Centre, Dr. D.Y Patil Vidyapeeth, Pimpri, Pune, India.
MBBS Student, Dr. D.Y Patil Medical College, Hospital and Research Centre, Dr. D.Y Patil Vidyapeeth, Pimpri, Pune, India.
Ann Afr Med. 2023 Jan-Mar;22(1):112-116. doi: 10.4103/aam.aam_15_22.
Polycystic Ovarian Syndrome (PCOS) is an endocrinopathy with a complex metabolic disorder. PCOS is characterized by reproductive hormonal imbalances leading to the clinical presentation of hyperandrogenism and infertility. PCOS is also showing an increased prevalence of several other conditions such as obesity, dyslipidemia, hypertension, metabolic syndrome and type 2 diabetes mellitus (DM2) when compared with women without PCOS. The principal symptoms in patients with PCOS are irregular menstruation, acne, and excessive amounts of androgenic hormones. The Rotterdam PCOS consensus workshop has given specific criteria to establish PCOS diagnosis only after exclusion of other known disorders. Obesity is a common finding of women with PCOS, but it is not part of the diagnostic criteria. PCOS has metabolic characteristics that include prominent defects in insulin action and beta-cell function, defects that confer a substantially increased risk for obesity and type 2 diabetes mellitus. PCOS women have an increased level of luteinizing hormone (LH) and a decreased level of follicle-stimulating hormone (FSH), which leads to disorders in the regulation of the menstrual cycle. The values of LH and FSH are dependent on the day of the menstrual cycle in which the hormones are measured. Obesity also has an influence on these values.
The objective of this study was to compare the hormonal and anthropometric parameters in women with PCOS and healthy control group.
This study was carried out in the Department of Pathology, Dr. D Y Patil Medical College and Research Centre, Pune, Maharashtra. Fifty female patients aged 16-40 years diagnosed with PCOS by known criteria were included in the study and compared with 50 healthy control group females.
Elevated levels of thyroid-stimulating hormone, LH, FSH, and prolactin along with increased body mass index and waist-to-hip ratio were predictors of PCOS and the early metabolic abnormalities.
多囊卵巢综合征（PCOS）是一种内分泌疾病，伴有复杂的代谢紊乱。PCOS 的特征是生殖激素失衡，导致高雄激素血症和不孕的临床表现。与没有 PCOS 的女性相比，PCOS 还表现出其他几种疾病的患病率增加，如肥胖、血脂异常、高血压、代谢综合征和 2 型糖尿病（DM2）。PCOS 患者的主要症状是月经不规律、痤疮和雄激素激素过多。罗得岛多囊卵巢综合征共识研讨会为 PCOS 诊断提供了具体标准，只有在排除其他已知疾病后才能确立 PCOS 诊断。肥胖是 PCOS 女性的常见现象，但它不是诊断标准的一部分。PCOS 具有代谢特征，包括胰岛素作用和β细胞功能的明显缺陷，这些缺陷使肥胖和 2 型糖尿病的风险大大增加。PCOS 女性的促黄体生成激素（LH）水平升高，促卵泡激素（FSH）水平降低，导致月经周期调节紊乱。LH 和 FSH 的值取决于测量激素的月经周期的天数。肥胖也会影响这些值。
本研究旨在比较多囊卵巢综合征患者和健康对照组的激素和人体测量参数。
本研究在马哈拉施特拉邦浦那的 Dr. D Y Patil 医科大学和研究中心的病理学系进行。纳入了 50 名年龄在 16-40 岁之间、符合已知标准的 PCOS 女性患者，并与 50 名健康对照组女性进行比较。
促甲状腺激素、LH、FSH 和催乳素水平升高，体重指数和腰臀比增加是 PCOS 和早期代谢异常的预测指标。
