2022 年，与乌克兰战争相关，德国的 NDM-1 和 NDM-1/OXA-48 产生增加。

Increase in NDM-1 and NDM-1/OXA-48-producing in Germany associated with the war in Ukraine, 2022.

机构信息

Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.

German National Reference Centre for Multidrug-resistant Gram-negative Bacteria, Department of Medical Microbiology, Ruhr-University Bochum, Bochum, Germany.

出版信息

Euro Surveill. 2022 Dec;27(50). doi: 10.2807/1560-7917.ES.2022.27.50.2200926.

DOI:10.2807/1560-7917.ES.2022.27.50.2200926

PMID:36695468

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9808319/

Abstract

In 2022, German surveillance systems observed rapidly increasing numbers of NDM-1- and NDM-1/OXA-48-producing , which may in part reflect recurring pre-pandemic trends. Among these cases, however, a presence in Ukraine before diagnosis was frequently reported. Whole genome sequencing of 200 isolates showed a high prevalence of sequence types ST147, ST307, ST395 and ST23, including clusters corresponding to clonal dissemination and suggesting onward transmission in Germany. Screening and isolation of patients from Ukraine may help avoid onward transmission.

摘要

2022 年，德国监控系统观察到携带 NDM-1 和 NDM-1/OXA-48 的不断增加，这在一定程度上可能反映出反复出现的大流行前趋势。然而，在这些病例中，经常有报道称在诊断之前在乌克兰就存在这些。对 200 株分离株进行全基因组测序显示，序列类型 ST147、ST307、ST395 和 ST23 的流行率很高，包括与克隆传播相对应的簇，并表明在德国的进一步传播。对来自乌克兰的患者进行筛查和隔离可能有助于避免进一步传播。