National Public Health Surveillance Laboratory (NVSPL), Vilnius, Lithuania.
European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Euro Surveill. 2024 Apr;29(16). doi: 10.2807/1560-7917.ES.2024.29.16.2400188.
In 2023, an increase of OXA-48-producing was noticed by the Lithuanian National Public Health Surveillance Laboratory. Whole genome sequencing (WGS) of 106 OXA-48-producing isolates revealed three distinct clusters of carbapenemase-producing high-risk clones, including sequence type (ST) 45 (n = 35 isolates), ST392 (n = 32) and ST395 (n = 28), involving six, six and nine hospitals in different regions, respectively. These results enabled targeted investigation and control, and underscore the value of national WGS-based surveillance for antimicrobial resistance.
2023 年，立陶宛国家公共卫生监测实验室注意到产 OXA-48 的 增加。对 106 株产 OXA-48 的 分离株进行全基因组测序（WGS）显示，产碳青霉烯酶的 高危克隆有三个不同的聚类，包括 序列型（ST）45（n = 35 株）、ST392（n = 32 株）和 ST395（n = 28 株），分别涉及不同地区的六家、六家和九家医院。这些结果使得能够进行有针对性的调查和控制，并强调了基于国家 WGS 的抗微生物药物耐药性监测的价值。
