Département des Maladies infectieuses et tropicales, Hôpital de la Croix-Rousse, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Univ Lyon, Lyon, France.
Euro Surveill. 2022 Dec;27(50). doi: 10.2807/1560-7917.ES.2022.27.50.2200882.
Modified vaccinia virus Ankara vaccine (MVA-BN; Bavarian Nordic) is recommended to contacts of mpox cases up to 14 days post-exposure but the effectiveness of this strategy is unknown. Among 108 adults (≥ 18 years old) who received one dose of MVA-BN after exposure to mpox, 11 (10%) cases of breakthrough mpox were observed. Sexual exposure was associated with the risk of breakthrough mpox (p = 0.0179). Samples taken from vaccinated breakthrough mpox cases had similar rates of infectious virus isolation than unvaccinated mpox cases.
改良安卡拉痘苗病毒疫苗（MVA-BN；巴伐利亚北欧公司）推荐用于猴痘病例的接触者，在接触后 14 天内使用，但这种策略的效果尚不清楚。在 108 名接触猴痘后接受一剂 MVA-BN 的成年人（≥18 岁）中，观察到 11 例（10%）突破性猴痘病例。性接触与突破性猴痘的风险相关（p=0.0179）。从接种突破性猴痘病例中采集的样本与未接种猴痘病例的病毒分离率相似。
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