Singapore National Eye Centre, Singapore Eye Research Institute, Singapore.
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Retina. 2023 Feb 1;43(2):303-312. doi: 10.1097/IAE.0000000000003651.
To report the pattern and characteristics of drusen subtypes in Asian populations and the association with choroidal thickness.
This is the cross-sectional analysis of the population-based cohort study. Two thousand three hundred and fifty-three eyes of 1,336 Chinese and Indian participants aged older than 50 years, eyes with best-corrected visual acuity better than 20/60, and without other retinal diseases were recruited. Pachydrusen, reticular pseudodrusen, soft and hard drusen were graded on both color fundus photographs, and optical coherence tomography imaging with automated segmentation yielding and measurements of choroidal thickness.
Nine hundred and fifty-five Chinese and 381 Indians were included in the final analysis. The pattern of pachydrusen, soft drusen, hard drusen, and reticular pseudodrusen was 14.0%, 3.7%, 12.5%, and 0.2%, respectively. Mean choroidal thickness was the thickest in eyes with pachydrusen (298.3 μm; 95% confidence interval: 290.5-306.1), then eyes with hard (298.1 μm; 95% confidence interval: 290.6-305.5) and soft drusen (293.7 μm; 95% confidence interval: 281.9-305.4) and thinnest in eyes without drusen (284.6 μm; 95% confidence interval: 280.5-288.7). Systemic associations of the various drusen subtypes also differed.
Patterns, characterization and choroidal thickness of drusen subtypes, and their associations provide insights into the Asian phenotypic spectrum of age-related macular degeneration and the underlying pathogenesis.
报告亚洲人群中玻璃膜疣亚型的模式和特征，以及其与脉络膜厚度的关系。
这是一项基于人群的队列研究的横断面分析。共招募了 1336 名年龄大于 50 岁的中国和印度参与者的 2353 只眼，这些眼的最佳矫正视力大于 20/60，且没有其他视网膜疾病。在彩色眼底照片上对厚玻璃膜疣、网状假性玻璃膜疣、软性和硬性玻璃膜疣进行分级，并使用自动分割成像和脉络膜厚度测量的光学相干断层扫描。
最终分析纳入了 955 名中国人和 381 名印度人。厚玻璃膜疣、软性玻璃膜疣、硬性玻璃膜疣和网状假性玻璃膜疣的模式分别为 14.0%、3.7%、12.5%和 0.2%。厚玻璃膜疣眼的脉络膜厚度最厚（298.3μm；95%置信区间：290.5-306.1），其次是硬性玻璃膜疣眼（298.1μm；95%置信区间：290.6-305.5）和软性玻璃膜疣眼（293.7μm；95%置信区间：281.9-305.4），无玻璃膜疣眼最薄（284.6μm；95%置信区间：280.5-288.7）。各种玻璃膜疣亚型的系统关联也不同。
玻璃膜疣亚型的模式、特征和脉络膜厚度及其相关性，为年龄相关性黄斑变性的亚洲表型谱和潜在发病机制提供了深入了解。
