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人类免疫缺陷病毒与肾脏疾病的最新进展

Updates on HIV and Kidney Disease.

作者信息

Cervantes C Elena, Atta Mohamed G

机构信息

Department of Medicine, Division of Nephrology, Johns Hopkins University, 1830 E. Monument Street, Suite 416, Baltimore, MD, 21218, USA.

出版信息

Curr HIV/AIDS Rep. 2023 Apr;20(2):100-110. doi: 10.1007/s11904-023-00645-1. Epub 2023 Jan 25.

Abstract

PURPOSE OF REVIEW

With the advent of antiretroviral therapy, HIV infection has become a chronic disease in developed countries.

RECENT FINDINGS

Non-HIV-driven risk factors for kidney disease, such as APOL1 risk variants and other genetic and environmental factors, have been discovered and are better described. Consequently, the field of HIV-associated kidney disease has evolved with greater attention given to traditional risk factors of CKD and antiretroviral treatment's nephrotoxicity. In this review, we explore risk factors of HIV-associated kidney disease, diagnostic tools, kidney pathology in HIV-positive individuals, and antiretroviral therapy-associated nephrotoxicity.

摘要

综述目的

随着抗逆转录病毒疗法的出现,在发达国家,HIV感染已成为一种慢性病。

最新发现

已发现并更清楚地描述了肾脏疾病的非HIV驱动风险因素,如APOL1风险变异以及其他遗传和环境因素。因此,HIV相关肾病领域不断发展,对CKD的传统风险因素和抗逆转录病毒治疗的肾毒性给予了更多关注。在本综述中,我们探讨了HIV相关肾病的风险因素、诊断工具、HIV阳性个体的肾脏病理学以及抗逆转录病毒治疗相关的肾毒性。

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