Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Ocul Immunol Inflamm. 2024 Aug;32(6):858-862. doi: 10.1080/09273948.2023.2168701. Epub 2023 Jan 25.
endophthalmitis is a severe complication of candidemia. Currently, the recommended treatment of fungal endophthalmitis is a combination of intravitreal and systemic antifungal drugs, and in some cases vitrectomy is also required. Intravitreal therapies that are commonly used are amphotericin B and voriconazole, although recently the use of intravitreal caspofungin has been described in a few case reports. However, clinical experience with intravitreal caspofungin is still limited.
We report a case of bilateral endophthalmitis, initially managed with repeated 100 μg/0.1 ml caspofungin intravitreal injections and posteriorly treated with pars plana vitrectomy in both eyes.
Intravitreal caspofungin could be a safe intravitreal alternative to habitual antimycotic drugs in cases with resistant endophthalmitis. Intensive Care Unit (ICU); Best-Corrected Visual Acuity (BCVA).
眼内炎是念珠菌血症的严重并发症。目前，真菌性眼内炎的推荐治疗方法是联合使用玻璃体内和全身抗真菌药物，在某些情况下还需要玻璃体切除术。常用的玻璃体内治疗方法是两性霉素 B 和伏立康唑，尽管最近在少数病例报告中描述了使用玻璃体内卡泊芬净。然而，玻璃体内卡泊芬净的临床经验仍然有限。
我们报告了一例双侧眼内炎病例，最初采用重复 100μg/0.1ml 卡泊芬净玻璃体内注射治疗，随后双眼均行玻璃体切除术。
在耐药性眼内炎的情况下，玻璃体内卡泊芬净可能是一种安全的玻璃体内替代常规抗真菌药物的方法。重症监护病房（ICU）；最佳矫正视力（BCVA）。
