Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, Guangzhou 510080, China.
Department of Epidemiology and Biostatistics, College of Public Health, Shandong University, Jinan 250102, China.
Ecotoxicol Environ Saf. 2023 Mar 1;252:114560. doi: 10.1016/j.ecoenv.2023.114560. Epub 2023 Jan 23.
Previous studies have shown a relationship between fine particulate matter (PM) exposure and an increased risk of neonatal disorders. Considering the huge burden of neonatal disorders, we assessed spatiotemporal trends of neonatal disorders burden caused by ambient and household PM at the global, regional, and national levels from 1990 to 2019. The number, rate, and population attributable fraction (PAF) of ambient and household PM-related neonatal disorders disability-adjusted life years (DALYs) in 204 countries and territories from 1990 to 2019 were obtained from the Global Burden of Disease Study 2019 to measure the related neonatal disorders burden by age, sex, subtype, and region. Estimated annual percentage change (EAPC) was estimated to quantify temporal trends. In 2019, approximately a fifth of the global neonatal disorders burden was attributable to PM exposure, with 7.54% for ambient PM and 13.23% for household PM. Although the global neonatal disorders burden attributable to household PM has decreased substantially in the past 30 years, that attributable to ambient PM has increased, especially in lower sociodemographic index (SDI) regions. The highest rate and PAF of ambient PM-related neonatal disorders DALYs in 2019 were in South Asia and East Asia, respectively, and the fastest increases were in Eastern Sub-Saharan Africa (for rate: EAPC = 2.55, 95% CI: 2.37-2.73) and South Asia (for PAF: EAPC = 3.88, 95% CI: 3.68-4.08). In addition, we found an inverted V-shaped between rates and PAFs of ambient PM-related neonatal disorders DALYs in 2019, as well as corresponding EAPCs, and SDI, while rates and PAFs of household PM-related neonatal disorders DALYs in 2019 were highly negatively correlated with SDI. In the past three decades, the global ambient PM-related neonatal disorders burden largely increased, especially in lower SDI regions. Comparatively, the household PM-related neonatal disorders burden decreased but still accounted for about two-thirds of the PM-related neonatal disease burden.
先前的研究表明，细颗粒物（PM）暴露与新生儿疾病风险增加之间存在关联。鉴于新生儿疾病的巨大负担，我们评估了 1990 年至 2019 年全球、区域和国家层面环境和家庭 PM 导致的新生儿疾病负担的时空趋势。从 1990 年至 2019 年，204 个国家和地区的全球疾病负担研究 2019 年获得了环境和家庭 PM 相关的新生儿疾病残疾调整生命年（DALY）的数量、比例和人群归因分数（PAF），以按年龄、性别、亚型和地区衡量相关的新生儿疾病负担。估计的年百分比变化（EAPC）用于量化时间趋势。2019 年，全球约五分之一的新生儿疾病负担归因于 PM 暴露，其中环境 PM 占 7.54%，家庭 PM 占 13.23%。尽管过去 30 年来，家庭 PM 导致的新生儿疾病负担有了显著下降，但环境 PM 导致的新生儿疾病负担却有所增加，尤其是在社会人口指数（SDI）较低的地区。2019 年，环境 PM 相关的新生儿疾病 DALY 的比率和 PAF 最高的地区分别是南亚和东亚，而增长率最快的地区是东撒哈拉以南非洲（比率：EAPC=2.55，95%置信区间：2.37-2.73）和南亚（PAF：EAPC=3.88，95%置信区间：3.68-4.08）。此外，我们发现 2019 年环境 PM 相关的新生儿疾病 DALY 的比率和 PAF 与 SDI 之间存在倒 V 形关系，以及相应的 EAPC，而 2019 年家庭 PM 相关的新生儿疾病 DALY 的比率和 PAF 与 SDI 高度负相关。在过去的三十年中，全球环境 PM 相关的新生儿疾病负担大大增加，尤其是在 SDI 较低的地区。相比之下，家庭 PM 相关的新生儿疾病负担有所下降，但仍占 PM 相关新生儿疾病负担的三分之二左右。
