富血小板血浆（PRP）宫腔内注射改善宫腔粘连患者子宫内膜容受性：基于时间序列的自身对照研究。

How platelet-rich plasma (PRP) intra-uterine injection improve endometrial receptivity of intrauterine adhesions in women: A time-series-based self-controlled study.

机构信息

Reproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, 510655 Guangzhou, China; GuangDong Engineering Technology Research Center of Fertility Preservation, 510655, Guangzhou, China.

出版信息

J Reprod Immunol. 2023 Mar;156:103796. doi: 10.1016/j.jri.2023.103796. Epub 2023 Jan 10.

DOI:10.1016/j.jri.2023.103796

PMID:36696783

Abstract

Platelet-rich plasma (PRP) treatment proven to improve fertility outcomes in patients with a poor endometrial environment. However, the mechanism is not yet clear. In this study, we recruited 6 patients with infertility due to IUA and 6 normal control women. The subjects in the IUA group collected samples before and after PRP treatment. Endometrial receptivity was improved after PRP treatment. After PRP treatment, the endometrial NK cells, CD8 T cells and Th1 cells were significantly lower than those before treatment. Functional enrichment analysis suggested that the effects of changes in microbial composition played an important role in changes in the endometrial immune environment. Among them, the most significant difference was Bacillus. Our self-controlled cohort in this study can fully describe the detailed mechanism by which PRP treatment improves the endometrial environment.

摘要

富血小板血浆（PRP）治疗已被证明可改善子宫内膜环境差的患者的生育结局。然而，其机制尚不清楚。在这项研究中，我们招募了 6 名因 IUA 导致不孕的患者和 6 名正常对照组女性。IUA 组的受试者在 PRP 治疗前后采集样本。PRP 治疗后子宫内膜容受性得到改善。PRP 治疗后，子宫内膜 NK 细胞、CD8 T 细胞和 Th1 细胞明显低于治疗前。功能富集分析表明，微生物组成变化的影响在子宫内膜免疫环境的变化中起着重要作用。其中，差异最显著的是芽孢杆菌。本研究中的自我对照队列可以充分描述 PRP 治疗改善子宫内膜环境的详细机制。