Chang Yajie, Li Jingjie, Wei Li-Na, Pang Jiahui, Chen Jianhui, Liang Xiaoyan
Center of Reproductive Medicine, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Medicine (Baltimore). 2019 Jan;98(3):e14062. doi: 10.1097/MD.0000000000014062.
Adequate thickness of the endometrium has been well recognized as a critical factor for embryo implantation. This was a prospective cohort study to investigate the benefits of platelet-rich plasma (PRP) for women with thin endometrium who received frozen embryo transfer (FET) program in a larger number of patients and explore the underlying mechanism.
In this study, we investigated the effects of PRP in women with thin endometrium in FET program. 64 patients with thin endometrium (<7 mm) were recruited. PRP intrauterine infusion was given in PRP group during hormone replacement therapy (HRT) cycle in FET cycles.
After PRP infusion, the endometrium thickness in PRP group was 7.65 ± 0.22 mm, which was significantly thicker than that in control group (6.52 ± 0.31 mm) (P <.05). Furthermore, PRP group had lower cycle cancellation rate when compared to control group (19.05% vs. 41.18%, P <.01). The implantation rate and clinical pregnancy rate in PRP group were significantly higher than those in control group (27.94% vs 11.67%, P <.05; 44.12% vs 20%, P <.05, respectively). PRP blood contained 4 folds higher platelets and significantly greater amounts of growth factors including platelet-derived growth factor (PDGF)-AB, PDGF-BB, and transforming growth factor (TGF)-β than peripheral blood (P <.01).
PRP plays a positive role in promoting endometrium proliferation, improving embryo implantation rate and clinical pregnancy rate for women with thin endometrium in FET cycles.
子宫内膜的适当厚度已被公认为胚胎着床的关键因素。这是一项前瞻性队列研究，旨在调查富血小板血浆（PRP）对大量接受冷冻胚胎移植（FET）方案的薄子宫内膜女性的益处，并探索其潜在机制。
在本研究中，我们调查了PRP在FET方案中对薄子宫内膜女性的影响。招募了64例薄子宫内膜（<7mm）的患者。PRP组在FET周期的激素替代治疗（HRT）周期中进行PRP宫腔内输注。
PRP输注后，PRP组的子宫内膜厚度为7.65±0.22mm，显著厚于对照组（6.52±0.31mm）（P<0.05）。此外，与对照组相比，PRP组的周期取消率更低（19.05%对41.18%，P<0.01）。PRP组的着床率和临床妊娠率显著高于对照组（分别为27.94%对11.67%，P<0.05；44.12%对20%，P<0.05）。PRP血液中的血小板含量比外周血高4倍，并且含有大量生长因子，包括血小板衍生生长因子（PDGF）-AB、PDGF-BB和转化生长因子（TGF）-β（P<0.01）。
PRP在促进FET周期中薄子宫内膜女性的子宫内膜增殖、提高胚胎着床率和临床妊娠率方面发挥着积极作用。
