Alonso-Frías Paula, Francés-Herrero Emilio, Bueno-Fernandez Clara, Gómez-Álvarez María, Agustina-Hernández Marcos, Cervelló Irene, Cozzolino Mauro
IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain.
Department of Pediatrics, Obstetrics and Gynecology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.
Biology (Basel). 2025 Mar 21;14(4):319. doi: 10.3390/biology14040319.
Platelet-rich plasma (PRP) is a concentrated product of autologous plasma platelets. It promotes the repair of tissues with low healing potential by providing supraphysiological amounts of essential growth factors and has recently become more popular in endometrial repair, achieving exciting clinical results. PRP treatment has proven to improve fertility outcomes in patients with a poor endometrial environment. However, the mechanism is not yet clear. Previous preclinical models also showed that PRP treatment decreased the expression of inflammatory markers and fibrosis, increased the endometrial proliferation rate and gene expression, and enhanced the pregnancy rate. The modulation of the endometrial immune environment and endometrial microbial community by PRP treatment appeared to be the key mechanism by which it improved endometrial receptivity. This review summarized the potential of adult PRP based on its composition and applications and the biological mechanisms and biological modifications in the endometrium after PRP instillation in preclinical models.
富血小板血浆（PRP）是自体血浆血小板的浓缩产物。它通过提供超生理量的必需生长因子来促进愈合潜力低的组织的修复，并且最近在子宫内膜修复中变得更受欢迎，取得了令人兴奋的临床结果。PRP治疗已被证明可改善子宫内膜环境不良患者的生育结局。然而，其机制尚不清楚。先前的临床前模型还表明，PRP治疗可降低炎症标志物的表达和纤维化，提高子宫内膜增殖率和基因表达，并提高妊娠率。PRP治疗对子宫内膜免疫环境和子宫内膜微生物群落的调节似乎是其改善子宫内膜容受性的关键机制。本综述总结了基于其组成和应用的成人PRP的潜力，以及临床前模型中PRP注入后子宫内膜的生物学机制和生物学修饰。
