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[血流动力学参数在判定肾移植功能中的价值(动物实验与临床观察)]

[Value of hemodynamic parameters in determining kidney transplant function (animal experiments and clinical observations)].

作者信息

Schuldt H H, Althaus P

出版信息

Z Urol Nephrol. 1978 Oct;71(10):693-8.

PMID:366970
Abstract

From the demonstrated results is to be concluded: 1. The haemodynamic and functional inquiries on animal experimental and clinical kidney grafts suppose that the tubules and the renal vascular system are comparably affected by the damaging influences of the different preservation methods. 2. This pathogenetic relationship is apparently maintained also in the regeneration phase; i.e. the tubular restitution is connected with an improvement of the blood-supply of the organ. 3. The discrepancy between the morphologic and functional findings of storage and perfusion preserved kidneys shows that the efficiency of the graft is not only defined by definitive structural changes, but also by other factors, such as metabolites, enzymatic and humoral influences, changes of the local blood composition, regional conditions of blood-supply, and so on. 4. Due to the significant relation between restrictions of the renal blood-supply and the renal function after transplantation haemodynamic parameters are suitable for the judgment of renal preservation methods and for the prognostic estimation of renal grafts.

摘要

从已证实的结果可以得出以下结论

  1. 对动物实验和临床肾移植进行的血流动力学和功能研究表明,不同保存方法的损伤性影响对肾小管和肾血管系统的影响具有可比性。2. 这种发病机制关系在再生阶段显然也得以维持;也就是说,肾小管的修复与器官血液供应的改善相关。3. 储存保存肾和灌注保存肾的形态学与功能学结果之间的差异表明,移植物的效能不仅由最终的结构变化决定,还受其他因素影响,如代谢产物、酶和体液影响、局部血液成分变化、局部血液供应状况等。4. 由于肾血液供应受限与移植后肾功能之间存在显著关联,血流动力学参数适用于评判肾保存方法以及对肾移植物进行预后评估。

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