Resegotti L, Palestro G, Novero D, Micca F B, Godio L, Pistone M, Garnero M, Levis A, Stramignoni A
Department of Haematology, San Giovanni Battista Regional Hospital, Molinette, Torino, Italy.
Leuk Res. 1987;11(9):789-95. doi: 10.1016/0145-2126(87)90063-4.
The immunologic phenotype of the lymphocytes of 100 patients with chronic lymphocytic leukaemia (CLL) was investigated. Peripheral blood lymphocytes (PBL) were examined in all cases; in 46 patients with lymphadenopathy, a lymph node was biopsied and the histologic and immunologic patterns were assessed: 24 had a lymphocytic-lymphoplasmocytoid histology and 22 the follicular variant of lymphocytic lymphoma (mantle zone lymphoma, MZL). For comparison, lymph node suspensions from 19 patients with non-leukemic centrocytic lymphoma (CCL) were also studied. Significant differences in the PBL immunologic features were found between stage O and stage I patients. The phenotype of the lymphocytes of patients with lymphocytic histology was similar to that of stage 0 CLL patients, whereas major differences were found between these patients and those with mantle zone histology. This enables these patients to be recognized easily on immunologic grounds.
对100例慢性淋巴细胞白血病（CLL）患者的淋巴细胞免疫表型进行了研究。所有病例均检测外周血淋巴细胞（PBL）；46例有淋巴结病的患者进行了淋巴结活检，并评估了组织学和免疫模式：24例具有淋巴细胞-淋巴浆细胞样组织学，22例为淋巴细胞淋巴瘤的滤泡变异型（套细胞淋巴瘤，MZL）。作为对照，还研究了19例非白血病性中心细胞淋巴瘤（CCL）患者的淋巴结悬液。发现0期和I期患者的PBL免疫特征存在显著差异。淋巴细胞组织学患者的淋巴细胞表型与0期CLL患者相似，而这些患者与套细胞组织学患者之间存在主要差异。这使得能够基于免疫学依据轻松识别这些患者。
