Janssen Renske M J, Lustenhouwer Renee, Cup Edith H C, van Alfen Nens, Ijspeert Jos, Helmich Rick C, Cameron Ian G M, Geurts Alexander C H, van Engelen Baziel G M, Graff Maud J L, Groothuis Jan T
Rehabilitation, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Rehabilitation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
J Neurol Neurosurg Psychiatry. 2023 Jun;94(6):474-481. doi: 10.1136/jnnp-2022-330296. Epub 2023 Jan 25.
Neuralgic amyotrophy (NA) is an acute inflammation of nerves within the brachial plexus territory leading to severe pain and multifocal paresis resulting in >60% of patients having residual complaints and functional limitations correlated with scapular dyskinesia. Our primary aim was to compare the effects of multidisciplinary rehabilitation (MR), focused on motor relearning to improve scapular dyskinesia and self-management strategies for reducing pain and fatigue, with usual care (UC) on shoulder, arm and hand functional capability in patients with NA.
In a non-blinded randomised controlled trial (RCT), patients with NA (aged≥18 years, scapular dyskinesia, >8 weeks after onset) were randomised to either an MR or an UC group. MR consisted of a diagnostic multidisciplinary consultation and eight sessions of physical and occupational therapy. Primary outcome was functional capability of the shoulder, arm and hand assessed with the Shoulder Rating Questionnaire-Dutch Language Version (SRQ-DLV).
We included 47 patients with NA; due to drop-out, there were 22 participants in MR and 15 in UC for primary analysis. The mean group difference adjusted for sex, age and SRQ-DLV baseline score was 8.60 (95%CI: 0.26 to 16.94, p=0.044). The proportion attaining a minimal clinically relevant SRQ-DLV improvement (≥12) was larger for the MR group (59%) than the UC group (33%) with a number needed to treat of 4.
This RCT shows that an MR programme focused on motor relearning to improve scapular dyskinesia, combined with self-management strategies for reducing pain and fatigue, shows more beneficial effects on shoulder, arm and hand functional capability than UC in patients with NA.
NCT03441347.
神经性肌萎缩(NA)是一种臂丛神经区域内的急性神经炎症,可导致严重疼痛和多灶性麻痹,超过60%的患者有残留症状以及与肩胛运动障碍相关的功能受限。我们的主要目的是比较多学科康复(MR)与常规护理(UC)对NA患者肩、臂和手部功能能力的影响,MR侧重于运动再学习以改善肩胛运动障碍以及自我管理策略以减轻疼痛和疲劳。
在一项非盲随机对照试验(RCT)中,将NA患者(年龄≥18岁,有肩胛运动障碍,发病8周后)随机分为MR组或UC组。MR包括一次多学科诊断咨询以及八次物理治疗和职业治疗。主要结局是用荷兰语版肩部评分问卷(SRQ-DLV)评估的肩、臂和手部功能能力。
我们纳入了47例NA患者;由于失访,MR组有22名参与者,UC组有15名参与者进行主要分析。经性别、年龄和SRQ-DLV基线评分调整后的组间平均差异为8.60(95%CI:0.26至16.94,p=0.044)。达到SRQ-DLV最小临床相关改善(≥12)的比例,MR组(59%)高于UC组(33%),治疗所需人数为4。
这项RCT表明,针对改善肩胛运动障碍的运动再学习的MR方案,结合减轻疼痛和疲劳的自我管理策略,对NA患者肩、臂和手部功能能力的益处比UC更多。
NCT03441347。