Bissette Andrew J
Communications Chemistry, .
Commun Chem. 2021 Nov 26;4(1):166. doi: 10.1038/s42004-021-00608-w.
Small changes in protein structure can have pronounced effects on protein–protein interactions, but quantifying this has only recently become possible. Now, the binding landscapes of three homologous enzyme–inhibitor complexes are quantified and shown to depend on whether the inhibitor binds its natural target or a structurally similar protein.
蛋白质结构的微小变化可能会对蛋白质-蛋白质相互作用产生显著影响，但直到最近才能够对这种影响进行量化。现在，三种同源酶-抑制剂复合物的结合图谱已被量化，并显示其取决于抑制剂是与其天然靶点结合还是与结构相似的蛋白质结合。
