通过镧系金属有机框架中的外层球相互作用检测紫外-可见沉默生物标志物氧化三甲胺。
Detection of the UV-vis silent biomarker trimethylamine-N-oxide via outer-sphere interactions in a lanthanide metal-organic framework.
作者信息
Min Hui, Chen Zhonghang, Han Zongsu, Wang Kunyu, Xu Jun, Shi Wei, Cheng Peng
机构信息
Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China.
School of Materials Science and Engineering & National Institute for Advanced Materials Center for Rare Earth and Inorganic Functional Materials, Tianjin Key Lab for Rare Earth Materials and Applications, Nankai University, Tianjin, 300350, China.
出版信息
Commun Chem. 2022 Jun 22;5(1):74. doi: 10.1038/s42004-022-00690-8.
Trimethylamine-N-oxide (TMAO) is a biomarker of the cardiovascular disease that is one of the leading causes of worldwide death. Facile detection of TMAO can significantly improve the survival rate of this disease by allowing early prevention. However, the UV-vis silent nature of TMAO makes it intricated to be detected by conventional sensing materials or analytical instruments. Here we show a bilanthanide metal-organic framework functionalized by borono group for the recognition of TMAO. Superior sensitivity, selectivity and anti-interference ability were achieved by the inverse emission intensity changes of the two lanthanide centers. The limit of detection is 15.6 μM, covering the clinical urinary concentration range of TMAO. A smartphone application was developed based on the change in R-G-B chromaticity. The sensing mechanism via a well-matched outer-sphere interaction governing the sensing function was studied in detail, providing fundamentals in molecular level for the design of advanced sensing materials for UV-Vis silent molecules.
氧化三甲胺（TMAO）是一种心血管疾病的生物标志物，而心血管疾病是全球死亡的主要原因之一。通过早期预防，对TMAO进行简便检测可显著提高该疾病的存活率。然而，TMAO在紫外-可见光谱范围内无信号的特性使得使用传统传感材料或分析仪器对其进行检测变得复杂。在此，我们展示了一种通过硼基团功能化的双镧系金属有机框架用于识别TMAO。通过两个镧系中心的反向发射强度变化实现了卓越的灵敏度、选择性和抗干扰能力。检测限为15.6 μM，覆盖了TMAO的临床尿液浓度范围。基于R-G-B色度变化开发了一款智能手机应用程序。详细研究了通过匹配良好的外层球相互作用控制传感功能的传感机制，为设计用于紫外-可见无信号分子的先进传感材料提供了分子水平的基础。
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